67747-09-5
67747-09-5
Chemical Structure
Prochloraz
Synonym(s): BTS 40542
- CAS No.: 67747-09-5
- Formula:C15H16Cl3N3O2
- Molecular Weight:376.67
IUPAC Name: N-propyl-N-(2-(2,4,6-trichlorophenoxy)ethyl)-1H-imidazole-1-carboxamide
InChIKey: TVLSRXXIMLFWEO-UHFFFAOYSA-N
SMILES: O=C(N1C=CN=C1)N(CCC)CCOC2=C(Cl)C=C(Cl)C=C2Cl
Biological Activity: Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM[1][2].
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Prochloraz | 99.85% | Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM. | ||||||||||||||||||||
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Prochloraz (Standard) | ≥98% | Prochloraz (Standard) is the analytical standard of Prochloraz. This product is intended for research and analytical applications. Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM. | ||||||||||||||||||||
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Prochloraz-d7 | Prochloraz-d7 (BTS 40542-d7) is the deuterium labeled Prochloraz (HY-B0845). Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-W653727BTS44596 -
Similarity Score 0.60
HY-19971ML239 -
Similarity Score 0.59
HY-119360Lilly 18947 free base -
Similarity Score 0.56
HY-W042438Bis(2,4,6-trichlorophenyl) oxalate -
Similarity Score 0.55
HY-135809A2764 dihydrochloride -
Similarity Score 0.54
HY-B08672,4-D Butyl ester -
Similarity Score 0.53
HY-116146CYM50179 -
Similarity Score 0.53
HY-179689SLC6A19-IN-5 -
Similarity Score 0.53
HY-14197ARClorgyline hydrochloride (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. E Antignac, et al. Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions. Toxicol Lett. 1990 Dec;54(2-3):309-15. [Content Brief]
- [2]. Anne Marie Vinggaard, et al. Prochloraz: an imidazole fungicide with multiple mechanisms of action. Int J Androl. 2006 Feb;29(1):186-92. [Content Brief]
