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  3. L-Ascorbic acid 2-phosphate magnesium

L-Ascorbic acid 2-phosphate magnesium  (Synonyms: 2-Phospho-L-ascorbic acid magnesium)

Cat. No.: HY-103701A Assay: 99.13%
COA Handling Instructions

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

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L-Ascorbic acid 2-phosphate magnesium Chemical Structure

L-Ascorbic acid 2-phosphate magnesium Chemical Structure

CAS No. : 113170-55-1

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Based on 1 publication(s) in Google Scholar

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Description

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1].
L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human corneal endothelial cells (HCECs) 
Concentration: 0.1 mM; 0.3 mM; 1.5 mM
Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days
Result: Stimulated HCEC cells growth.
Molecular Weight

292.56

Formula

C6H9O9P.3/2Mg

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](O1)[C@H](C[O-])O)=C(OP([O-])([O-])=O)C1=O.[1.5].[Mg+2]

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (85.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4181 mL 17.0905 mL 34.1810 mL
5 mM 0.6836 mL 3.4181 mL 6.8362 mL
10 mM 0.3418 mL 1.7091 mL 3.4181 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.13%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
L-Ascorbic acid 2-phosphate magnesium
Cat. No.:
HY-103701A
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