1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. L-Ascorbic acid 2-phosphate magnesium

L-Ascorbic acid 2-phosphate magnesium (Synonyms: 2-Phospho-L-ascorbic acid magnesium)

Cat. No.: HY-103701A
Handling Instructions

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

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L-Ascorbic acid 2-phosphate magnesium Chemical Structure

L-Ascorbic acid 2-phosphate magnesium Chemical Structure

CAS No. : 113170-55-1

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Description

L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

IC50 & Target

IC50: alkaline phosphatase (ALP); collagen formation; runx2A[2][3]

In Vitro

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1].
L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex[3].

Cell Viability Assay[1]

Cell Line: Human corneal endothelial cells (HCECs) 
Concentration: 0.1 mM; 0.3 mM; 1.5 mM
Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days
Result: Stimulated HCEC cells growth.
Molecular Weight

292.56

Formula

C₆H₉O₉P.₃/₂Mg

CAS No.

113170-55-1

SMILES

OC([[email protected]](O1)[[email protected]](C[O-])O)=C(OP([O-])([O-])=O)C1=O.[1.5].[Mg+2]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

L-Ascorbic acid 2-phosphate2-Phospho-L-ascorbic acidPhosphatasehASCosteogenicdifferentiationmediumsupplementrunx2Avitamin?C,?derivativeInhibitorinhibitorinhibit

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L-Ascorbic acid 2-phosphate magnesium
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