1. Anti-infection
    Cell Cycle/DNA Damage
    Autophagy
  2. SARS-CoV
    Deubiquitinase
    Autophagy
  3. 6-Thioguanine

6-Thioguanine (Synonyms: Thioguanine;2-Amino-6-purinethiol)

Cat. No.: HY-13765 Purity: >98.0%
Handling Instructions

6-Thioguanine (Thioguanine) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

For research use only. We do not sell to patients.

6-Thioguanine Chemical Structure

6-Thioguanine Chemical Structure

CAS No. : 154-42-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 84 In-stock
Estimated Time of Arrival: December 31
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Description

6-Thioguanine (Thioguanine) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

IC50 & Target

IC50: 25 μM (PLpros), 40 μM (Recombinant human USP2)[3]

In Vitro

6-Thioguanine (Thioguanine) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively[1]. 6-Thioguanine (Thioguanine) affects the methylation of cytosine residues by purified DNA methyltransferases including human DNMT1 and bacterial HpaII methylase. 6-Thioguanine (Thioguanine) (1 or 3 μM) decreases global cytosine methylation in Jurkat T cells and cytosine methylation in human cells at 3 μM[2]. 6-Thioguanine (Thioguanine) (18.75, 37.50, or 75.00 μM) adversely affects cell viability, but with no effect on LDH or ALT activity[3].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (59.81 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9812 mL 29.9061 mL 59.8122 mL
5 mM 1.1962 mL 5.9812 mL 11.9624 mL
10 mM 0.5981 mL 2.9906 mL 5.9812 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[3]

Treatments consists of 3 thiopurines (azathioprine, 6-mercaptopurine, and 6-Thioguanine (Thioguanine)) at each of 6 concentrations (0.468, 0.937, 1.875, 3.750, 7.500, and 15.000 μM). Each thiopurinee is dissolved in DMSO solution to achieve a concentration of 10 mg/mL. Sterile filtered maintenance medium is used to further dilute each thiopurine solution to each of the 6 treatment concentrations. Twenty-four hours after the hepatocytes are plated on 96-well culture[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

167.19

Formula

C₅H₅N₅S

CAS No.

154-42-7

SMILES

SC1=NC(N)=NC2=C1N=CN2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
6-Thioguanine
Cat. No.:
HY-13765
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6-Thioguanine

Cat. No.: HY-13765