1020149-73-8
1020149-73-8
Chemical Structure
SGI-1027
- CAS No.: 1020149-73-8
- Formula:C27H23N7O
- Molecular Weight:461.52
IUPAC Name: N-(4-((2-amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide
InChIKey: QSYLKMKIVWJAAK-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3
Biological Activity: SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
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SGI-1027 | 99.79% | SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. | ||||||||||||||||||||
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