1. Vitamin D Related/Nuclear Receptor Apoptosis
  2. Nuclear Hormone Receptor 4A/NR4A Paraptosis
  3. 4-PQBH

4-PQBH 

Cat. No.: HY-115901 Purity: 99.08%
COA Handling Instructions

4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research.

For research use only. We do not sell to patients.

4-PQBH Chemical Structure

4-PQBH Chemical Structure

CAS No. : 2243355-51-1

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1].

IC50 & Target

Nur77/NR4A1

 

Molecular Weight

367.40

Formula

C22H17N5O

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N/N=C/C1=CC=NC=C1)C2=CC=C(NC3=CC=NC4=CC=CC=C34)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (68.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7218 mL 13.6091 mL 27.2183 mL
5 mM 0.5444 mL 2.7218 mL 5.4437 mL
10 mM 0.2722 mL 1.3609 mL 2.7218 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
4-PQBH
Cat. No.:
HY-115901
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