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Paraptosis

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-115901
    4-PQBH

    		Nuclear Hormone Receptor 4A/NR4A Paraptosis Cancer
    4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research .
    4-PQBH
  • HY-157974
    [Ag(2,2′-bipy)(dppe)][CF3SO3]

    		Apoptosis Cancer
    [Ag(2,2′-bipy)(dppe)][CF3SO3] (compound 4) can induce cell paraptosis, and can be used for stusy of resistant ovarian cancer .
    [Ag(2,2′-bipy)(dppe)][CF3SO3]
  • HY-156242
    BQZ-485

    		Apoptosis Cancer
    BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events .
    BQZ-485
  • HY-19625A
    (E/Z)-MCB-613

    		Reactive Oxygen Species Cancer
    (E/Z)-MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. (E/Z)-MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. (E/Z)-MCB-613 is a cytotoxic molecule that plays an important role in cancer .
    (E/Z)-MCB-613
  • HY-155719
    fac-[Re(CO)3(L3)(H2O)][NO3]

    		Paraptosis Cancer
    fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC50=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy .
    fac-[Re(CO)3(L3)(H2O)][NO3]

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