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Cat. No.: HY-157974

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[Ag(2,2′-bipy)(dppe)][CF3SO3]

[Ag(2,2′-bipy)(dppe)][CF3SO3] (compound 4) can induce cell paraptosis, and can be used for stusy of resistant ovarian cancer.

For research use only. We do not sell to patients.

Formula: C₃₇H₃₂AgF₃N₂O₃P₂S^-
Molecular Weight:811.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

[Ag(2,2′-bipy)(dppe)][CF3SO3] Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

[Ag(2,2′-bipy)(dppe)][CF3SO3] (compound 4) can induce cell paraptosis, and can be used for stusy of resistant ovarian cancer^[1].

In Vitro

[Ag(2,2′-bipy)(dppe)][CF3SO3] (compound 4) (0-10 μM,72 h) inhibits cell growth of SK-OV-3, SK-OV-3/CBP, HCT116 WT and HCT116 WT/OxR with the IC₅₀ values of 6.8 μM, 5.48 μM, 0.70 μM and 0.65 μM, respectively^[1].
[Ag(2,2′-bipy)(dppe)][CF3SO3] (10 μM, 24 h) induces cell apoptosis of SK-OV-3 and MES-OV cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SK-OV-3、SK-OV-3/CBP、HCT116 WT and HCT116 WT/OxR cells.
Concentration:

0-10 μM
Incubation Time:

72 h
Result:

Inhibited cell growth with the IC₅₀ values of 6.8 μM, 5.48 μM, 0.70 μM and 0.65 μM of SK-OV-3, SK-OV-3/CBP, HCT116 WT and HCT116 WT/OxR , respectively.

Apoptosis Analysis^[1]

Cell Line:

SK-OV-3 and MES-OV cells
Concentration:

10 μM
Incubation Time:

24 h
Result:

Induced cell apoptosis.

Chemical Information

Molecular Weight 811.54
Formula C₃₇H₃₂AgF₃N₂O₃P₂S^-
SMILES

FC(F)(S(=O)([O-])=O)F.C1([P]2(CC[P](C3=CC=CC=C3)([Ag]24[N]5=CC=CC=C5C6=CC=CC=[N]64)C7=CC=CC=C7)C8=CC=CC=C8)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Teixeira RG, et al. Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands. J Med Chem. Published online February 24, 2024. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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