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Cat. No.: HY-185041

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CHD1L-IN-2

CHD1L-IN-2 is a CHD1L inhibitor and exhibits cytotoxicity against tumor cells.

For research use only. We do not sell to patients.

CAS No.: 1251542-88-7
Formula: C₂₄H₂₄N₆O
Molecular Weight:412.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CHD1L-IN-2 Chemical Structure

CAS No.: 1251542-88-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

CHD1L-IN-2 is a CHD1L inhibitor and exhibits cytotoxicity against tumor cells^[1]^[2].

All DNA/RNA Synthesis Isoforms :

In Vitro

CHD1L-IN-2 (Compound 6.3) (72 h) has IC₅₀ values of 3.6 and 3.7 μM for SW620 and HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1251542-88-7
Molecular Weight 412.50
Formula C₂₄H₂₄N₆O
SMILES

O=C(NC1=CC=C(C=C1)NC2=NC(=NC(=C2)C)N3CCCC3)C4=CNC=5C=CC=CC54
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daniel V. LABARBERA, et al. Small molecule inhibitors of oncogenic chd1l with preclinical activity against colorectral cancer. WO2023055763A2. 2023-04-06.

[2]. Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022 Mar 10;65(5):3943-3961. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CHD1L-IN-2

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CHD1L-IN-2 Related Classifications

HY-185041 Related Classifications