1. Autophagy
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  3. Aumitin

Aumitin 

Cat. No.: HY-124726 Purity: 99.64%
COA Handling Instructions

Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively.

For research use only. We do not sell to patients.

Aumitin Chemical Structure

Aumitin Chemical Structure

CAS No. : 946293-78-3

Size Price Stock Quantity
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2980 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].

Molecular Weight

429.90

Formula

C24H20ClN5O

CAS No.
SMILES

O=C(NC1=CC=C(NC2=NC(NC3=CC=CC=C3)=CC(C)=N2)C=C1)C4=CC=CC=C4Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3261 mL 11.6306 mL 23.2612 mL
5 mM 0.4652 mL 2.3261 mL 4.6522 mL
10 mM 0.2326 mL 1.1631 mL 2.3261 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
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Product Name:
Aumitin
Cat. No.:
HY-124726
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