2929308-79-0
2929308-79-0
Chemical Structure
MY-1B
- CAS No.: 2929308-79-0
- Formula:C22H18BrN3O2
- Molecular Weight:436.30
InChIKey: DXMLBCROCLGUDK-DYESRHJHSA-N
SMILES: O=C([C@H]1[C@@H](C2=CC=C(C=C2)Br)CN1C(C=C)=O)NC3=CC=CC4=C3N=CC=C4
Biological Activity: MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MY-1B | 99.94% | MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.88
HY-169147MY-11B -
Similarity Score 0.52
HY-108437Rexo-IWR-1 (Standard) -
Similarity Score 0.52
HY-12238IWR-1 -
Similarity Score 0.51
HY-D1264PMQA -
Similarity Score 0.47
HY-111440MC-04124 -
Similarity Score 0.46
HY-P4528Ala-Phe-Pro-βNA -
Similarity Score 0.46
HY-113641ROCK-IN-32 -
Similarity Score 0.46
HY-P4303H-Gly-Trp-βNA -
Similarity Score 0.45
HY-W011063Gly-Phe-β-naphthylamide -
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References
- [1]. Tao Y, et al. Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2. Angew Chem Int Ed Engl. 2023 Dec 18;62(51):e202311924. [Content Brief]
- [2]. Tao Y, et al. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. J Am Chem Soc. 2022 Oct 12;144(40):18688-18699. [Content Brief]
- [3]. Ng BW, et al. Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics. Mol Cell. 2023 May 18;83(10):1544-1546. [Content Brief]
