Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics

  • Mol Cell. 2023 May 18;83(10):1544-1546. doi: 10.1016/j.molcel.2023.04.028.
Billy Wai-Lung Ng  1 ,  Tongyang Xu  2 ,  Zhihao Guo  2
Affiliations
  • 1. School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: [email protected].
  • 2. School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
PMID: 37207621 DOI: 10.1016/j.molcel.2023.04.028
Abstract

Most human proteins lack small-molecule ligands, rendering these proteins "undruggable." In this issue of Molecular Cell, Lazear et al.1 develop a novel chemical proteomic screening platform and discover new chemical probes targeting previously undruggable protein complexes.

Products