1640353-78-1
Chemical Structure
AT-1965
- CAS No.: 1640353-78-1
- Formula:C39H67N3O5Pt
- Molecular Weight:853.05
InChIKey: PJVKGFHWRSKEAS-BQHDTCDWSA-L
SMILES: [H][C@@]12CC=C3C[C@H](CC[C@@]3([C@]1(CC[C@@]4([C@H](CC[C@@]24[H])[C@H](C)CCCC(C)C)C)[H])C)OCC[N]5(CC([O-])=O)[Pt+]6([O]C(C5)=O)[NH2][C@@](CCCC7)([H])[C@]7([H])[NH2]6
Biological Activity: AT-1965 is a selective CMTR2 inhibitor that suppresses methyltransferase activity. AT-1965 triggers the intrinsic antiviral immune response in cancer cells, promotes the infiltration and activation of B cells into tumors, and thereby induces antitumor immune memory to prevent tumor recurrence. AT-1965 can be formulated into lipid nanoparticles to achieve rapid tumor regression. AT-1965 is widely used in studies of immunologically "cold" tumors, triple-negative breast cancer, melanoma, Lewis lung cancer, and other malignancies[1].
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AT-1965 | AT-1965 is a selective CMTR2 inhibitor that suppresses methyltransferase activity. AT-1965 triggers the intrinsic antiviral immune response in cancer cells, promotes the infiltration and activation of B cells into tumors, and thereby induces antitumor immune memory to prevent tumor recurrence. AT-1965 can be formulated into lipid nanoparticles to achieve rapid tumor regression. AT-1965 is widely used in studies of immunologically "cold" tumors, triple-negative breast cancer, melanoma, Lewis lung cancer, and other malignancies. | |||||||||||||||||||||
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