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Checkpoint Kinase (Chk) Related Products (44)
Related Products (44)
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Monalizumab
0 ImagesSynonyms: IPH2201Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC).
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Theaflavin-3-gallate
0 ImagesTheaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through p53-dependent pathways. Theaflavin-3-gallate induces DNA damage through ATM/Chk/p53 pathway.
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LY2880070
0 ImagesLY2880070 is an orally active CHK1 inhibitor, IC50 ＜ 1 nM. LY2880070 can be used as an anticancer agent for combination with DNA damaging agents.
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M2I-1
0 ImagesM2I-1 is a Mad2 inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the spindle assembly checkpoint (SAC).
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Heraclenin
0 ImagesHeraclenin is a linear furanocoumarin natural product. Heraclenin binds to the type III effector protein XopQ and chitin deacetylase, exhibits antibacterial activity against Xanthomonas oryzae pv. oryzae, and displays antifungal activity against Colletotrichum lindemuthianum. Heraclenin stimulates Runx2 mRNA expression, induces osteoblast differentiation and mineralization. Heraclenin induces Chk1 phosphorylation, G2/M cell cycle arrest, DNA fragmentation, apoptosis, chromosomal aberrations, sister chromatid exchange, and inhibits proliferation. Heraclenin can be used for research on osteoporosis, melanoma, T-cell lymphoma, and leukemia.
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GDC-0575-d4
0 ImagesCat. No.: HY-112167SSynonyms: ARRY-575-d4; RG7741-d4GDC-0575-d4 (ARRY-575-d4) is the deuterium labeled GDC-0575 (HY-112167). GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.
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(S)-1-Boc-3-aminopiperidine
0 ImagesSynonyms: (S)-(+)-3-Amino-1-boc-piperidine
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Lisavanbulin
0 ImagesSynonyms: BAL-101553Lisavanbulin (BAL-101553) is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin is a BBB-penetrant and orally active antitumor agent, especially in tumors that express high levels of end-binding protein 1. Lisavanbulin has ability to target tumor cell proliferation and affects the tumor microenvironment by reducing tumor microvasculature. Lisavanbulin is also a spindle assembly checkpoint activator. Lisavanbulin induces cell cycle arrest and subsequent death or aberrant chromosome segregation. Lisavanbulin can be studied in research for diffuse large B cell lymphoma (DLBCL) and glioblastoma.
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ML367
0 ImagesML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
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Lisavanbulin dihydrochloride
0 ImagesSynonyms: BAL-101553 dihydrochlorideLisavanbulin (BAL-101553) dihydrochloride is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin dihydrochloride exhibits antitumor activity, especially in tumors that express high levels of end-binding protein 1. Lisavanbulin dihydrochloride has ability to target tumor cell proliferation and affects the tumor microenvironment by reducing tumor microvasculature. Lisavanbulin dihydrochloride is also a spindle assembly checkpoint activator. Lisavanbulin dihydrochloride induces cell cycle arrest and subsequent death or aberrant chromosome segregation. Lisavanbulin dihydrochloride can be studied in research for diffuse large B cell lymphoma (DLBCL) and glioblastoma.
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CHEK1 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS02616CHEK1 Human Pre-designed siRNA Set A contains three designed siRNAs for CHEK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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CHK1-IN-7
0 ImagesCat. No.: HY-103367CAS No.: 838823-31-7
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K1586
0 ImagesCat. No.: HY-161622Purity: 99.63%K1586 is an amidine derivative that efficiently targets Chk1. K1586 enhances the degradation of Chk1 that sensitizes colorectal cancer cells to ionizing radiation. K1586 shows anticancer effects.
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Zimistobart
0 ImagesCat. No.: HY-P991058CAS No.: 2829290-06-2Synonyms: BMS-986315Zimistobart (BMS-986315) is a fully human IgG1 antibody that targets NKG2A. Zimistobart can be used for the study of non-small cell lung cancer (NSCLC). The isotype control for Zimistobart can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Prexasertib-d4
0 ImagesCat. No.: HY-18174SPurity: 98.41%Synonyms: LY2606368-d4Prexasertib-d4 (LY2606368-d4) is the deuterium labeled Prexasertib (HY-18174). Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity.
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NSC 109555
0 ImagesCat. No.: HY-123597CAS No.: 15427-93-7Synonyms: DDUG; NCI C04808NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2; IC50=200 nM in a cell-free kinase assay). It is selective for Chk2 over Chk1 and 16 kinases in a panel but does inhibit Brk, c-Met, IGFR, and LCK with IC50 values of 210, 6,000, 7,400, and 7,100 nM, respectively. NSC 109555 inhibits Chk2 autophosphorylation and phosphorylation of the Chk2 substrate histone H1 in vitro (IC50=240 nM). It inhibits the growth of, and induces autophagy in, L1210 leukemia cells in vitro.2 NSC 109555 (1,250 nM) potentiates gemcitabine-induced cytotoxicity in MIA PaCa-2, CFPAC-1, PANC-1, and BxPC-3 pancreatic cancer cells, as well as reduces gemcitabine-induced increases in Chk2 phosphorylation and enhances gemcitabine-induced production of reactive oxygen species (ROS) in MIA PaCa-2 cells.
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Chek1 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS02618Chek1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chek1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
