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Checkpoint Kinase (Chk) Related Products (43)
Related Products (43)
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CHEK2 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS02619CHEK2 Human Pre-designed siRNA Set A contains three designed siRNAs for CHEK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Ziptide
0 ImagesCat. No.: HY-P10367CAS No.: 518069-98-2
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Chek2 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS02620Chek2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chek2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Chek2 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS02621Chek2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Chek2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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BPTQ
0 ImagesCat. No.: HY-124122CAS No.: 1802665-43-5BPTQ is a potent inhibitor against VEGFR1 and CHK2 with IC50 values of 0.54 and 1.70 µmol/L, respectively. BPTQ is also an intercalator of DNA with anticancer activities. BPTQ inhibits the proliferation of HL-60 cells by arresting cells at S and G2/M phase with an IC50 value of 12 µmol/L. BPTQ also activates the mitochondria-mediated Apoptosis pathway by a decrease in mitochondrial membrane potential, increase in the Bax:Bcl-2 ratio and activation of caspases.
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Graviquinone
0 ImagesCat. No.: HY-180357CAS No.: 1383995-51-4Graviquinone is a Chk1 inhibitor. Graviquinone exhibits potent cytotoxicity against various cancer cell lines. Graviquinone possesses the characteristics of bypassing ABCB1-mediated multidrug resistance, selectively damaging cancer cell DNA, and regulating the DNA damage response. Graviquinone can also enhance cytotoxicity by increasing ROS levels in cancer cells. Graviquinone can be used for cancer research.
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Apoptosis inducer 49
0 ImagesCat. No.: HY-178940Apoptosis inducer 49 is a selective apoptosis inducer with high specificity against CCRF-CEM leukemia cells (IC50 = 2.68 μM). Apoptosis inducer 49 enhances RNA synthesis and replication stress, activates the Chk1-p21 axis, leading to S-phase arrest. Apoptosis inducer 49 can inhibit Bcl-2 and activate caspase-3. Apoptosis inducer 49 can be used for the study of Leukemia.
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Theaflavin-3-gallate (Standard)
0 ImagesCat. No.: HY-N0245RCAS No.: 30462-34-1Theaflavin-3-gallate (Standard) is the analytical standard of Theaflavin-3-gallate. This product is intended for research and analytical applications. Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner. Theaflavin-3-gallate induces apoptosis and G1 cell cycle arrest in ovarian cancer A2780/CP70 cells through p53-dependent pathways. Theaflavin-3-gallate induces DNA damage through ATM/Chk/p53 pathway.
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CBP501 Affinity Peptide
0 ImagesCat. No.: HY-P4978CAS No.: 1351804-17-5CBP501 Affinity Peptide is a Chk kinase inhibitor that can abrogate G2 arrest induced by DNA-damaging agents. CBP501 Affinity Peptide can be used in cancer research.
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NSC 109555 ditosylate
0 ImagesCat. No.: HY-103366CAS No.: 66748-43-4NSC 109555 ditosylate is a potent, selective, ATP-competitive checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 240 nM. NSC 109555 ditosylate can be used for the research of cancer.
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Zn-DPA-maytansinoid conjugate 1
0 ImagesCat. No.: HY-151559CAS No.: 3034629-04-1Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an "inflamed hot tumor" .
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FLT3/CHK1-IN-2
0 ImagesCat. No.: HY-162367FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of FLT3 and CHK1, with IC50s of 25.63, 16.39, 22.80 nM for CHK1, FLT3-WT, and FLT-D835Y respectively. FLT3/CHK1-IN-2 has favorable oral PK properties and kinase selectivity. FLT3/CHK1-IN-2 can be used for research of acute myeloid leukemia (AML).
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Chktide
0 ImagesCat. No.: HY-P5961CAS No.: 289652-77-3Chktide is a synthetic peptide substrate applicable for activity assays of Chk1 kinase and cyk/CaMKII. Chktide contains the Ser53 phosphorylation site of Xenopus cyclin B2.
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(S)-CCT245737
0 ImagesCat. No.: HY-18958ACAS No.: 1489389-23-2Synonyms: (S)-SRA737(S)-CCT245737 ((S)-SRA737) is a potent and selective oral inhibitor of checkpoint kinase 1 (CHK1).
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Chek1 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS02617Chek1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Chek1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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XL-844
0 ImagesCat. No.: HY-124774CAS No.: 631864-00-1Synonyms: EXEL-9844
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M2I-1 (Standard)
0 ImagesCat. No.: HY-100341RCAS No.: 312271-03-7
