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M2I-1 

Cat. No.: HY-100341
Handling Instructions

M2I-1 a small Mad2 inhibitor-1.

For research use only. We do not sell to patients.

M2I-1 Chemical Structure

M2I-1 Chemical Structure

CAS No. : 312271-03-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 192 In-stock
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 360 In-stock
Estimated Time of Arrival: December 31
25 mg USD 732 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2160 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. It can also inhibited the Mad2-F-Mbp1 interaction in FP assays.

Molecular Weight

404.48

Formula

C₁₉H₂₄N₄O₄S

CAS No.

312271-03-7

SMILES

O=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (79.11 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4723 mL 12.3616 mL 24.7231 mL
5 mM 0.4945 mL 2.4723 mL 4.9446 mL
10 mM 0.2472 mL 1.2362 mL 2.4723 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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M2I-1
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