3034629-04-1
Chemical Structure
Zn-DPA-maytansinoid conjugate 1
- CAS No.: 3034629-04-1
- Formula:C115H145ClN18O31S2Zn2
- Molecular Weight:2505.83
IUPAC Name: methyl 7-methyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate
InChIKey: RDSDTLFAEVXKAG-IKYTVVMDSA-N
SMILES: [O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.C[C@H](C(O[C@@H](CC(N1C)=O)[C@](O2)(C)C2[C@@H](C)[C@@H]3OC(N[C@](O)([C@H](/C=C\C=C(CC4=CC(OC)=C(C1=C4)Cl)/C)OC)C3)=O)=O)N(C(CCSSCCC(NCC5=CC=C(CNC(COCCOCCOCC(N(CCCCOC6=CC(C[N]78CC9=CC=CC=[N]9[Zn+2]7[N](C(NC(CCCCC)=O)=CC=C%10)=C%10C8)=CC(C[N]%11%12CC%13=CC=CC=[N]%13[Zn+2]%11[N](C(NC(CCCCC)=O)=CC=C%14)=C%14C%12)=C6)CC%15=CC=C(C=C%15)C%16=CC=CC=C%16)=O)=O)C=C5)=O)=O)C
Biological Activity: Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an "inflamed hot tumor" [1].
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Zn-DPA-maytansinoid conjugate 1 | Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an "inflamed hot tumor" . | |||||||||||||||||||||
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Keywords
