2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. MU380

MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity.

For research use only. We do not sell to patients.

MU380 Chemical Structure

MU380 Chemical Structure

CAS No. : 2109805-78-7

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Description

MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity[1].

In Vitro

MU380 (100 nM, 24 h) potently inhibits CHK1 kinase and sensitizes lymphoid tumor cells to gemcitabine[1].
MU380 (400 nM, 24 h) can significantly affect the cell cycle profile and induce the death of dividing and non-dividing primary chronic lymphocytic leukemia lymphocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MU380 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MEC-1and MEC-2 cells
Concentration: 400 nM
Incubation Time: 24 h
Result: Showed accumulation in S phase as well as reduction in G2/M phase, greatly reduced rate of DNA synthesis, and marked induction of apoptosis (PARP protein cleavage).

Western Blot Analysis[1]

Cell Line: Chronic lymphocytic leukemia cells
Concentration: 100 nM or 200 nM
Incubation Time: 24 h
Result: Potently blocked CHK1 activation while enhancing ATR kinase signaling to CHK1 (pS317 and pS345), and resulted in decreased levels of total CDC25A and CDC25C, pY15 CDK1, cyclin B1 and cyclin E1.
In Vivo

MU380 (20 mg/kg, in 20% aqueous Kolliphor solution, every three days from day 14 to day 28) can effectively inhibit tumor growth in NOD-scid IL2Rγnull mice with tumour[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-scid IL2Rγnull mice[1]
Dosage: 20 mg/kg
Administration: In 20% aqueous Kolliphor solution, every three days from day 14 to day 28
Result: Significantly inhibit the growth of tumors and gradually reduce their volume, with an average reduction of about 61%.
Molecular Weight

430.23

Formula

C15H15BrF3N7
CAS No.
SMILES

NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C(F)(F)F)N=C4)C=NN13
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MU380 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU3802109805-78-7MU 380MU-380Checkpoint Kinase (Chk)CHK1apoptosisanticancerInhibitorinhibitorinhibit

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