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Cat. No.: HY-112167S

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GDC-0575-d₄

Name: GDC-0575-d4
Brand: MedChemExpress
SKU: HY-112167S
Availability: PreOrder

(Synonyms: ARRY-575-d₄; RG7741-d₄)

GDC-0575-d₄ (ARRY-575-d₄) is the deuterium labeled GDC-0575 (HY-112167). GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC₅₀ of 1.2 nM.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₆D₄BrN₅O
Molecular Weight:382.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GDC-0575-d₄ Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Protocols (1)
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GDC-0575-d₄ (ARRY-575-d₄) is the deuterium labeled GDC-0575 (HY-112167). GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC₅₀ of 1.2 nM.

All Checkpoint Kinase (Chk) Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 1196541-47-5
Molecular Weight 382.29
Formula C₁₆H₁₆D₄BrN₅O
SMILES

O=C(C1C([2H])([2H])C1([2H])[2H])NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32
Synonyms

ARRY-575-d₄; RG7741-d₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Protocols
Purity & Documentation

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GDC-0575-d4

All Checkpoint Kinase (Chk) Isoforms