381168-77-0
Chemical Structure
ML367
- CAS No.: 381168-77-0
- Formula:C19H12F2N4
- Molecular Weight:334.32
IUPAC Name: N-(3,4-difluorophenyl)-2-(pyridin-4-yl)quinazolin-4-amine
InChIKey: LBPYNNJXARHGAG-UHFFFAOYSA-N
SMILES: FC1=CC(NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42)=CC=C1F
Biological Activity: ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1].
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ML367 | 99.84% | ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. | ||||||||||||||||||||
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Keywords
