1. Metabolic Enzyme/Protease
  2. PGC-1α
  3. ZLN005

ZLN005 

Cat. No.: HY-17538 Purity: 99.69%
Handling Instructions

ZLN005 is a potent transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).

For research use only. We do not sell to patients.

ZLN005 Chemical Structure

ZLN005 Chemical Structure

CAS No. : 49671-76-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ZLN005 purchased from MCE. Usage Cited in: Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691.

    The protein expression levels of COI~IV and the phosphorylation levels of Akt and GSK3β in the NEFA+ZLN005 group are significantly higher than in the non-esterified fatty acid (NEFA) group.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    ZLN005 is a potent transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].

    IC50 & Target

    Peroxisome proliferator-activated receptor-γ coactivator-1α[1]

    In Vitro

    ZLN005 (2.5-20 μM; 24 hours ) activates AMPK in a dose-dependent manner[1].

    Western Blot Analysis[1]

    Cell Line: L6 myotubes
    Concentration: 2.5, 5, 10, 20 μM
    Incubation Time: 24 hours
    Result: Dose-dependent activation of AMPK.
    In Vivo

    ZLN005 (15 mg/kg; p.o.; per day for 4 weeks) decreases random blood glucose and fasting blood glucose levels over 4 weeks compared with lean mice[1].

    Animal Model: Eight-week-old db/db mice[1]
    Dosage: 15 mg/kg
    Administration: Oral administration; per day for 4 weeks
    Result: Random blood glucose and fasting blood glucose levels decreased significantly over 4 weeks compared with lean mice.
    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 47 mg/mL (187.74 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9946 mL 19.9728 mL 39.9457 mL
    5 mM 0.7989 mL 3.9946 mL 7.9891 mL
    10 mM 0.3995 mL 1.9973 mL 3.9946 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    250.34

    Formula

    C₁₇H₁₈N₂

    CAS No.

    49671-76-3

    SMILES

    CC(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)(C)C

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.69%

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    ZLN005
    Cat. No.:
    HY-17538
    Quantity:

    ZLN005

    Cat. No.: HY-17538