1. Metabolic Enzyme/Protease
  2. PGC-1α
  3. ZLN005

ZLN005 

Cat. No.: HY-17538 Purity: 99.69%
Handling Instructions

ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).

For research use only. We do not sell to patients.

ZLN005 Chemical Structure

ZLN005 Chemical Structure

CAS No. : 49671-76-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Top Publications Citing Use of Products

    ZLN005 purchased from MCE. Usage Cited in: Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691.

    The protein expression levels of COI~IV and the phosphorylation levels of Akt and GSK3β in the NEFA+ZLN005 group are significantly higher than in the non-esterified fatty acid (NEFA) group.
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    Description

    ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). IC50 value: Target: PGC-1α in vitro: ZLN005 increases expression of the PGC-1α gene in L6 myotubes. ZLN005 increased PGC-1α mRNA levels in a dose-dependent manner; 20 μmol/L ZLN005 caused a threefold increase over the control after 24 h. At 10 μmol/L, the PGC-1α mRNA levels were increased to almost the same extent at 16 to 48 h [1]. ZLN005 did not increase the expression of the PGC-1α gene in rat primary hepatocytes. AMP-activated protein kinase is involved in the mechanism inducing PGC-1α in L6 myotubes [1] in vivo: An insulin tolerance test revealed that treatment with ZLN005 significantly decreased insulin resistance in db/db mice, as evidenced by the approximately 18% decrease in the AUC. A PTT also was performed in db/db mice, and ZLN005 improved pyruvate tolerance, as evidenced by the 16% decrease in the AUC. In db/db mice, plasma NEFA and triglyceride levels were decreased by 20% and 37%, respectively, and cholesterol was decreased by 10% with ZLN005 treatment. Plasma insulin and β-hydroxybutyrate content, liver/bodyweight index and adipose composition, and muscle and liver triglyceride levels, however, were not ameliorated by treatment with ZLN005 or metformin [1].

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 47 mg/mL (187.74 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9946 mL 19.9728 mL 39.9457 mL
    5 mM 0.7989 mL 3.9946 mL 7.9891 mL
    10 mM 0.3995 mL 1.9973 mL 3.9946 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    250.34

    Formula

    C₁₇H₁₈N₂

    CAS No.

    49671-76-3

    SMILES

    CC(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)(C)C

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.69%

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    Product Name:
    ZLN005
    Cat. No.:
    HY-17538
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    ZLN005

    Cat. No.: HY-17538