49671-76-3
49671-76-3
Chemical Structure
ZLN005
- CAS No.: 49671-76-3
- Formula:C17H18N2
- Molecular Weight:250.34
IUPAC Name: 2-(4-(tert-butyl)phenyl)-1H-benzo[d]imidazole
InChIKey: LQUNNCQSFFKSSK-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)(C)C
Biological Activity: ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZLN005 | 99.05% | ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). | ||||||||||||||||||||
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ZLN005 (Standard) | ≥98% | ZLN005 (Standard) is the analytical standard of ZLN005 (HY-17538). This product is intended for research and analytical applications. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). | ||||||||||||||||||||
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ZLN005-d4 | 99.52% | ZLN005-d4 is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). | ||||||||||||||||||||
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TNKS-IN-1 | 99.55% | TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 can antagonize the Wnt signal transduction pathway by stabilizing axin proteins and promoting β-catenin degradation. TNKS-IN-1 can be used for the research of colorectal cancer. | ||||||||||||||||||||
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2-(3-Chlorophenyl)-1H-benzo[d]imidazole | 2-(3-Chlorophenyl)-1H-benzo[d]imidazole is an antibacterial agent. 2-(3-Chlorophenyl)-1H-benzo[d]imidazole can be used in the research of bacterial infections and fungal infections. | |||||||||||||||||||||
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β-catenin-IN-2 | 99.55% | β-catenin-IN-2 (Compound H1B1) is a potent β-catenin inhibitor. β-catenin-IN-2 can be used for the study of colorectal cancer. | ||||||||||||||||||||
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NADH-IN-2 | NADH-IN-2 (compund 8) is a Type II NADH dehydrogenase inhibitor. | |||||||||||||||||||||
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ZLN005 hydrochloride | ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity. | |||||||||||||||||||||
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BE2012 | 99.49% | BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels. | ||||||||||||||||||||
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Chlorfenazole | 99.85% | Chlorfenazole (o-Chlorobenzimidazole) is a benzimidazole-based compound. Chlorfenazole is used in the research of intestinal nematode diseases. | ||||||||||||||||||||
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2-(2′-Hydroxyphenyl)benzimidazole | 99.92% | 2-(2′-Hydroxyphenyl) benzimidazole is the most extensively studied excited-state intramolecular proton transfer (ESIPT) molecule, exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl) benzimidazole has been applied as a fluorescent probe in various systems. | ||||||||||||||||||||
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V-161 | 99.61% | V-161 is the orally active inhibitor for Na+-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 µg/mL and 4 µg/mL. V-161 inhibits colonization of VRE in mouse small intestine. | ||||||||||||||||||||
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