ZLN005 hydrochloride

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ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity.

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CAS No. : 2319647-97-5

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Other In-stock Forms of ZLN005 hydrochloride:

ZLN005

Other Forms of ZLN005 hydrochloride:

ZLN005-d₄ In-stock
ZLN005 In-stock
ZLN005-d₄ hydrochloride Get quote

48 Publications Citing Use of MCE ZLN005 hydrochloride

Histological Imaging/Staining

: ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]; The intraoral photographs of rats in diabetic periodontitis group (DP) and ZLN005 (0.1 mg/mL, 30 μL) intervened diabetic periodontitis group (DP + ZLN005).

: ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]; Vernier caliper was used to measure the periodontal probing depth in both groups, and we found that ZLN005 (0.1 mg/mL, 30 μL) could largely reduce the periodontal probing depth (0.82 ± 0.08 mm vs 0.54 ± 0.07 mm), and the difference was statistically significant.

: ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]; TEM images revealed that after the intervention of ZLN005 (0.1 mg/mL, 30 μL), the morphology and structure of mitochondria in the rat gingival tissues were basically restored to normal, which indicating that mitochondria homeostatic imbalance was ameliorated in DP + ZLN005 group.

: ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]; HE and Masson staining verified that the less infiltrating inflammatory cells and the less fractured collagen fibers were found in the gingival connective tissues of DP + ZLN005 (0.1 mg/mL, 30 μL) group.

: ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]; Western blot demonstrated that there were decreased protein levels of MMP1 and MMP3, whereas increased levels of TIMP1 and COL1A1 in DP + ZLN005 group, which suggested the disturbance of ECM remodeling in gingival connective tissues of DP rats was effectively improved.

: ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Cytokine. 2023 May:165:156186. [Abstract]; ZLN005 (10, 20 μM; 6 h) increases the protein levels of TAC1, Bax, Bim, cleaved Caspase 1 (C-CAP1), and cleaved Caspase 9 (C-CAP9) in a dose-dependent manner in HL-1 cells.

: ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691. [Abstract]; The protein expression levels of COI~IV and the phosphorylation levels of Akt and GSK3β in the NEFA+ZLN005 group are significantly higher than in the non-esterified fatty acid (NEFA) group.

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Description	ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity^[1].
Molecular Weight	286.80
Formula	C₁₇H₁₉ClN₂
CAS No.	2319647-97-5
SMILES	CC(C)(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)C.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Zhang LN, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307. [Content Brief]