ZLN005 hydrochloride
Based on 49 publication(s) in Google Scholar
ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity.
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- CAS No.: 2319647-97-5
- Formula: C17H19ClN2
- Molecular Weight:286.80
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) ZLN005 hydrochloride
More- Mol Cell. 2023 Dec 7;83(23):4370-4385.e9. [Abstract]
- Adv Sci (Weinh). 2024 Jun;11(22):e2400749. [Abstract]
- Redox Biol. 2025 Aug 22:86:103829. [Abstract]
- Metabolism. 2023 Aug:145:155592. [Abstract]
- J Hazard Mater. 2023 Oct 5:459:132262. [Abstract]
- Genes Dis. 2020 Dec 23;8(6):891-906. [Abstract]
- Free Radic Biol Med. 2026 May 19:253:18-35. [Abstract]
- J Transl Med. 2023 Jul 20;21(1):486. [Abstract]
- Int Endod J. 2025 Jul 14. [Abstract]
- Cell Death Discov. 2025 Jul 29;11(1):351. [Abstract]
- Cell Death Discov. 2025 Jul 2;11(1):299. [Abstract]
- Cell Mol Life Sci. 2025 Aug 8;82(1):303. [Abstract]
- J Agric Food Chem. 2024 Jul 17;72(28):15740-15754. [Abstract]
- Cells. 2024 Aug 29;13(17):1448. [Abstract]
- Life Sci. 2026 Apr 15:391:124281. [Abstract]
- CNS Neurosci Ther. 2023 Mar;29(3):941-956. [Abstract]
- Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691. [Abstract]
- Pharmaceuticals (Basel). 2022 Mar 31;15(4):434. [Abstract]
- Front Pharmacol. 2022 Mar 3;13:834570. [Abstract]
- Int Immunopharmacol. 2024 May 14:134:112248. [Abstract]
- Neuropharmacology. 2025 Feb 12:269:110361. [Abstract]
- J Dairy Sci. 2023 Feb;106(2):1315-1329. [Abstract]
- Mol Neurobiol. 2025 Dec 16;63(1):303. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Apr 26;1871(6):167874. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Apr 6;1870(5):167158. [Abstract]
- Environ Toxicol Pharmacol. 2024 Mar:106:104393. [Abstract]
- J Inflamm Res. 2024 Nov 4:17:8135-8146. [Abstract]
- Neurochem Int. 2025 Sep 26:106061. [Abstract]
- Cell Calcium. 2025 Aug 26:132:103071. [Abstract]
- J Funct Foods. 2023 Nov, 110, 105825.
- Aging. 2021 Mar 10;13(6):8421-8439. [Abstract]
- Aging (Albany NY). 2020 Apr 28;12(8):7411-7430. [Abstract]
- Brain Res Bull. 2025 Apr 30:111365. [Abstract]
- Cytokine. 2023 May:165:156186. [Abstract]
- Food Chem Toxicol. 2025 Apr 25:115488. [Abstract]
- Mol Med Rep. 2020 Jul;22(1):155-164. [Abstract]
- BMC Complement Med Ther. 2020 Aug 17;20(1):255. [Abstract]
- Toxicol Appl Pharmacol. 2019 Aug 1:376:17-37. [Abstract]
- Neurotox Res. 2024 Jun 17;42(4):30. [Abstract]
- Front Biosci (Landmark Ed). 2024 Jul 23;29(7):263. [Abstract]
- Reprod Toxicol. 2022 Oct:113:18-29. [Abstract]
- Am J Transl Res. 2021 Sep 15;13(9):10014-10037. [Abstract]
- bioRxiv. 2025 Oct 22.
- medRxiv. 2025 Oct 13.
- SSRN. 2024 Apr 17.
- Research Square Preprint. 2021 Nov.
- Research Square Preprint. 2021 Jul.
- Oxid Med Cell Longev. 2020 Nov 26;2020:4830418. [Abstract]
- Evid Based Complement Alternat Med. 2020 Mar 9;2020:4845028. [Abstract]
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Biological Activity
Chemical Information
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CAS No. 2319647-97-5
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Molecular Weight 286.80
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Formula C17H19ClN2
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SMILES
CC(C)(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (49)
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Journal Impact Factor
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Most Recent
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Mol Cell
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. [Abstract]2023 Dec 7;83(23):4370-4385.e9. PMID: 38016475 -
Adv Sci (Weinh)
PGC1α-Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D-Overexpressing Cell Membranes for Intervertebral Disc Degeneration. [Abstract]2024 Jun;11(22):e2400749. PMID: 38554394 -
Redox Biol
PGC-1α-mediated mitochondrial homeostasis imbalance aggravated gingival lesions of diabetic periodontitis by disrupting ECM remodeling of human gingival fibroblast. [Abstract]2025 Aug 22:86:103829. PMID: 40865270
ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]
The intraoral photographs of rats in diabetic periodontitis group (DP) and ZLN005 (0.1 mg/mL, 30 μL) intervened diabetic periodontitis group (DP + ZLN005).
ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]
Vernier caliper was used to measure the periodontal probing depth in both groups, and we found that ZLN005 (0.1 mg/mL, 30 μL) could largely reduce the periodontal probing depth (0.82 ± 0.08 mm vs 0.54 ± 0.07 mm), and the difference was statistically significant.
ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]
TEM images revealed that after the intervention of ZLN005 (0.1 mg/mL, 30 μL), the morphology and structure of mitochondria in the rat gingival tissues were basically restored to normal, which indicating that mitochondria homeostatic imbalance was ameliorated in DP + ZLN005 group.
ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]
HE and Masson staining verified that the less infiltrating inflammatory cells and the less fractured collagen fibers were found in the gingival connective tissues of DP + ZLN005 (0.1 mg/mL, 30 μL) group.
ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Aug 22:86:103829. [Abstract]
Western blot demonstrated that there were decreased protein levels of MMP1 and MMP3, whereas increased levels of TIMP1 and COL1A1 in DP + ZLN005 group, which suggested the disturbance of ECM remodeling in gingival connective tissues of DP rats was effectively improved.
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Metabolism
2023 Aug:145:155592. PMID: 37230215 -
J Hazard Mater
Daucosterol confers protection against T-2 toxin induced blood-brain barrier toxicity through the PGC-1α-mediated defensive response in vitro and in vivo. [Abstract]2023 Oct 5:459:132262. PMID: 37604032 -
Genes Dis
PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes. [Abstract]2020 Dec 23;8(6):891-906. PMID: 34522716 -
Free Radic Biol Med
Nanoplastic exposure induces mitochondrial dysfunction-driven inflammation and senescence in renal tubular epithelial cells. [Abstract]2026 May 19:253:18-35. PMID: 42162843 -
J Transl Med
An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway. [Abstract]2023 Jul 20;21(1):486. PMID: 37475042 -
Int Endod J
Sympathetic nerves inhibit dental pulp stem cell differentiation and tertiary dentine formation via α1B-adrenergic receptor. [Abstract]2025 Jul 14. PMID: 40660609 -
Cell Death Discov
Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson's disease through inhibition of H3K4me3 demethylation. [Abstract]2025 Jul 29;11(1):351. PMID: 40730642 -
Cell Death Discov
DNMBP-AS1/hsa-miR-30a-5p/PGC1α axis suppresses tumor progression of colorectal cancer by inhibiting PKM2-mediated Warburg effect and enhance anti-PD-1 therapy efficacy. [Abstract]2025 Jul 2;11(1):299. PMID: 40603870 -
Cell Mol Life Sci
PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia. [Abstract]2025 Aug 8;82(1):303. PMID: 40779200 -
J Agric Food Chem
Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling. [Abstract]2024 Jul 17;72(28):15740-15754. PMID: 38970822 -
Cells
ZLN005, a PGC-1α Activator, Protects the Liver against Ischemia-Reperfusion Injury and the Progression of Hepatic Metastases. [Abstract]2024 Aug 29;13(17):1448. PMID: 39273020 -
Life Sci
Oxytocin ameliorates cardiac hypertrophy by inhibiting mitochondrial dysfunction and pyroptosis via AMPK/PGC-1α /TFAM pathway. [Abstract]2026 Apr 15:391:124281. PMID: 41722768 -
CNS Neurosci Ther
Alpha-Asarone modulates kynurenine disposal in muscle and mediates resilience to stress-induced depression via PGC-1α induction. [Abstract]2023 Mar;29(3):941-956. PMID: 36575869 -
Int J Mol Sci
Berberine Protects against NEFA-Induced Impairment of Mitochondrial Respiratory Chain Function and Insulin Signaling in Bovine Hepatocytes. [Abstract]2018 Jun 6;19(6). pii: E1691. PMID: 29882814
ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691. [Abstract]
The protein expression levels of COI~IV and the phosphorylation levels of Akt and GSK3β in the NEFA+ZLN005 group are significantly higher than in the non-esterified fatty acid (NEFA) group.
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Pharmaceuticals (Basel)
ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis. [Abstract]2022 Mar 31;15(4):434. PMID: 35455432 -
Front Pharmacol
5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation. [Abstract]2022 Mar 3;13:834570. PMID: 35308244 -
Int Immunopharmacol
Diosmetin ameliorates psoriasis-associated inflammation and keratinocyte hyperproliferation by modulation of PGC-1α / YAP signaling pathway. [Abstract]2024 May 14:134:112248. PMID: 38749332 -
Neuropharmacology
ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa. [Abstract]2025 Feb 12:269:110361. PMID: 39952351 -
J Dairy Sci
Sirtuin 3 relieves inflammatory responses elicited by lipopolysaccharide via the PGC1α-NFκB pathway in bovine mammary epithelial cells. [Abstract]2023 Feb;106(2):1315-1329. PMID: 36494223 -
Mol Neurobiol
ZLN005 Alleviates the Dopaminergic Degeneration via PGC-1α-Mediated Mitochondrial Homeostasis in Parkinson's Disease. [Abstract]2025 Dec 16;63(1):303. PMID: 41400900 -
Biochim Biophys Acta Mol Basis Dis
PGC-1α role in rescuing ferroptosis in cerebral ischemia/reperfusion injury through promoting mitochondrial biogenesis and UCP2 expression. [Abstract]2025 Apr 26;1871(6):167874. PMID: 40294850 -
Biochim Biophys Acta Mol Basis Dis
Cholesterol 25-hydroxylase prevents type 2 diabetes mellitus induced cardiomyopathy by alleviating cardiac lipotoxicity. [Abstract]2024 Apr 6;1870(5):167158. PMID: 38588780 -
Environ Toxicol Pharmacol
2024 Mar:106:104393. PMID: 38367920 -
J Inflamm Res
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders. [Abstract]2024 Nov 4:17:8135-8146. PMID: 39525311 -
Neurochem Int
Spinal p38 MAPK/PGC-1α/SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation. [Abstract]2025 Sep 26:106061. PMID: 41016638 -
Cell Calcium
Silencing CALB1 enhances prostate cancer radiosensitivity via calcium-mediated mitochondrial dysfunction and cellular senescence. [Abstract]2025 Aug 26:132:103071. PMID: 40902499 -
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Aging
PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury. [Abstract]2021 Mar 10;13(6):8421-8439. PMID: 33714196 -
Aging (Albany NY)
PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells. [Abstract]2020 Apr 28;12(8):7411-7430. PMID: 32343674 -
Brain Res Bull
Activation of spinal PGC-1α regulates microglial polarization through a feedback loop between ROS-mediated mitochondrial dysfunction and the NLRP3 inflammasome in neuropathic pain. [Abstract]2025 Apr 30:111365. PMID: 40316183 -
Cytokine
The Src1-PGC1α-AP1 complex-dependent secretion of substance P induces inflammation and apoptosis in encephalomyocarditis virus-infected mice. [Abstract]2023 May:165:156186. PMID: 36989655
ZLN005 hydrochloride purchased from MedChemExpress. Usage Cited in: Cytokine. 2023 May:165:156186. [Abstract]
ZLN005 (10, 20 μM; 6 h) increases the protein levels of TAC1, Bax, Bim, cleaved Caspase 1 (C-CAP1), and cleaved Caspase 9 (C-CAP9) in a dose-dependent manner in HL-1 cells.
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Food Chem Toxicol
Mechanisms of LPS-induced toxicity in endothelial cells and the protective role of geniposidic acid. [Abstract]2025 Apr 25:115488. PMID: 40288513 -
Mol Med Rep
p53/PGC‑1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis. [Abstract]2020 Jul;22(1):155-164. PMID: 32377739 -
BMC Complement Med Ther
Identification of volatile active components in Acori Tatarinowii Rhizome essential oil from different regions in China by C6 glioma cells. [Abstract]2020 Aug 17;20(1):255. PMID: 32807141 -
Toxicol Appl Pharmacol
BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in vivo. [Abstract]2019 Aug 1:376:17-37. PMID: 31085209 -
Neurotox Res
PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice. [Abstract]2024 Jun 17;42(4):30. PMID: 38884699 -
Front Biosci (Landmark Ed)
Telomerase Reverse Transcriptase Regulates Intracellular Ca2+ Homeostasis and Mitochondrial Function via the p53/PGC-1α Pathway in HL-1 Cells. [Abstract]2024 Jul 23;29(7):263. PMID: 39082363 -
Reprod Toxicol
Melatonin attenuates di-(2-ethylhexyl) phthalate-induced apoptosis of human granulosa cells by inhibiting mitochondrial fission. [Abstract]2022 Oct:113:18-29. PMID: 35952901 -
Am J Transl Res
ZLN005 protects against ischemia-reperfusion-induced kidney injury by mitigating oxidative stress through the restoration of mitochondrial fatty acid oxidation. [Abstract]2021 Sep 15;13(9):10014-10037. PMID: 34650679 -
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Oxid Med Cell Longev
The Nrf2/PGC1 α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer. [Abstract]2020 Nov 26;2020:4830418. PMID: 33294122 -
Evid Based Complement Alternat Med
The Essential Oil from Acori Tatarinowii Rhizome (the Dried Rhizome of Acorus tatarinowii Schott) Prevents Hydrogen Peroxide-Induced Cell Injury in PC12 Cells: A Signaling Triggered by CREB/PGC-1 α Activation. [Abstract]2020 Mar 9;2020:4845028. PMID: 32215040
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