β-catenin-IN-2
Based on 3 publication(s) in Google Scholar
β-catenin-IN-2 (Compound H1B1) is a potent β-catenin inhibitor. β-catenin-IN-2 can be used for the study of colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 1458664-10-2
- Formula: C15H14FN3
- Molecular Weight:255.29
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) β-catenin-IN-2
More
Biological Activity
β-catenin-IN-2 (10-40 μM) suppresses the transcriptional activity of the β-catenin/Tcf-4 in a dose-dependent manner in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1458664-10-2
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Appearance Solid
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Molecular Weight 255.29
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Formula C15H14FN3
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Color Pink to red
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SMILES
CN(C)C1=CC=C(C2=NC3=CC=C(F)C=C3N2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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J Immunother Cancer
CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation. [Abstract]2025 Oct 23;13(10):e012162. PMID: 41135952 -
Pharmacol Res
GSTA1/CTNNB1 axis facilitates sorafenib resistance via suppressing ferroptosis in hepatocellular carcinoma. [Abstract]2024 Nov 5:210:107490. PMID: 39510148 -
Aging (Albany NY)
Type I collagen promotes tumor progression of integrin β1 positive gastric cancer through a BCL9L/β-catenin signaling pathway. [Abstract]2021 Jul 28;13(14):19064-19076. PMID: 34319913
Solvent & Solubility
DMSO : 83.33 mg/mL (326.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9171 mL | 19.5856 mL | 39.1711 mL | 97.9278 mL |
| 5 mM | 0.7834 mL | 3.9171 mL | 7.8342 mL | 19.5856 mL | |
| 10 mM | 0.3917 mL | 1.9586 mL | 3.9171 mL | 9.7928 mL | |
| 15 mM | 0.2611 mL | 1.3057 mL | 2.6114 mL | 6.5285 mL | |
| 20 mM | 0.1959 mL | 0.9793 mL | 1.9586 mL | 4.8964 mL | |
| 25 mM | 0.1567 mL | 0.7834 mL | 1.5668 mL | 3.9171 mL | |
| 30 mM | 0.1306 mL | 0.6529 mL | 1.3057 mL | 3.2643 mL | |
| 40 mM | 0.0979 mL | 0.4896 mL | 0.9793 mL | 2.4482 mL | |
| 50 mM | 0.0783 mL | 0.3917 mL | 0.7834 mL | 1.9586 mL | |
| 60 mM | 0.0653 mL | 0.3264 mL | 0.6529 mL | 1.6321 mL | |
| 80 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL | 1.2241 mL | |
| 100 mM | 0.0392 mL | 0.1959 mL | 0.3917 mL | 0.9793 mL |
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