UCH-L3
UCH-L3, the close paralog of UCH-L1, is encoded by the UCHL3 gene and shares the compact, single-domain architecture typical of ubiquitin C-terminal hydrolases. Unlike the largely neuronal UCH-L1, UCH-L3 is expressed broadly across many tissues and hydrolyzes ubiquitin C-terminal fusions, peptide amides and small esters to replenish the free ubiquitin pool. A distinctive feature is its ability to also process the ubiquitin-like protein NEDD8, contributing to neddylation turnover. The enzyme has been implicated in the cellular response to genotoxic stress, and its expression is elevated in several malignancies, supporting interest in UCH enzymes as research tools and drug targets.
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UCH-L3 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
