1. Cell Cycle/DNA Damage
  2. PPAR

Wy-14643 (Synonyms: Pirinixic acid)

Cat. No.: HY-16995 Purity: 99.69%
Handling Instructions

Wy-14,643 (Pirinixic acid) is a moderate agonist of PPARα and PPARγ with IC50 of 36.5 μM and 53.7 μM, respectively.

For research use only. We do not sell to patients.
Wy-14643 Chemical Structure

Wy-14643 Chemical Structure

CAS No. : 50892-23-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
10 mg USD 60 In-stock
50 mg USD 84 In-stock
100 mg USD 120 In-stock
250 mg USD 264 In-stock
500 mg   Get quote  
1 g   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Wy-14,643 (Pirinixic acid) is a moderate agonist of PPARα and PPARγ with IC50 of 36.5 μM and 53.7 μM, respectively. IC50 value: 36.5 μM (for PPARα), 53.7 μM (for PPARγ) [2] Target: PPARα, PPARγ in vitro: Wy-14,643 is a moderate agonist of PPARα and PPARγ, leads to low micromolar active balanced dual agonists of PPARα and PPARγ. [1] The aliphatic substitution in α-position of the carboxylic acid head group of Wy-14,643 leads to more potent dual PPARα/γ agonists with a significant preference towards PPARα. Wy-14,643 exhibits beneficial effects in various inflammation-related processes in a slow, long-termed fashion. [2] in vivo: Wy-14,643 shows beneficial effects in animal models of inflammation and cardiovascular diseases that rely on slow-acting transcriptional events modulating protein expression. Wy-14,643 reduces the expression and production of cytokines, adhesion molecules, inducible NO synthase, heme oxygenase-1, and cyclooxygenase-2. Wy-14,643 inhibits human aldose reductase activity and increased uncoupling of oxidative phosphorylation in isolated mitochondria. [2]

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.0883 mL 15.4416 mL 30.8833 mL
5 mM 0.6177 mL 3.0883 mL 6.1767 mL
10 mM 0.3088 mL 1.5442 mL 3.0883 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 15 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.69%

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