2. PROTAC Apoptosis Immunology/Inflammation Cell Cycle/DNA Damage Autophagy Metabolic Enzyme/Protease
  3. Proteasome Cap Targeting Chimeras FKBP Proteasome
  4. RAFKBP12

RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination.
(Pink: FKBP12 ligand (HY-114434); Blue: Proteasome ligand (HY-181499); Black: linker).

For research use only. We do not sell to patients.

RAFKBP12

RAFKBP12 Chemical Structure

CAS No. : 2375455-59-5

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RAFKBP12 Related Antibodies

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Description

RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination[1]. (Pink: FKBP12 ligand (HY-114434); Blue: Proteasome ligand (HY-181499); Black: linker).

In Vitro

RAFKBP12 (1-10 μM; 24 h) induces degradation of FKBP12 in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RAFKBP12 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 1, 2.5, 10 μM
Incubation Time: 24 h
Result: Induced degradation of FKBP12 in HEK293T cells, as detected by western blotting.
Molecular Weight

1526.42

Formula

C79H93Cl4N5O17
CAS No.
SMILES

O=C([C@@H]1CCCCN1C([C@@H](CC)C2=CC(OC)=C(OC)C(OC)=C2)=O)O[C@@H](C3=CC=CC(OCC(NCCOCCOCCOCCC(NCCOCCN[C@H](C(N4C/C(C(/C(C4)=C/C5=CC(Cl)=C(Cl)C=C5)=O)=C\C6=CC=C(Cl)C(Cl)=C6)=O)CC7=CC=CC=C7)=O)=O)=C3)CCC8=CC(OC)=C(OC)C=C8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RAFKBP12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RAFKBP122375455-59-5RAFKBP 12RAFKBP-12Proteasome Cap Targeting ChimerasFKBPProteasomeCAP-TACsFK506-binding proteinubiquitinationdegradationproteasomeHEK293T cellsFKBP12Inhibitorinhibitorinhibit

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HY-181498
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