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Cat. No.: HY-128978

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(E,E)-RAMB4

(E,E)-RAMB4 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1.

For research use only. We do not sell to patients.

CAS No.: 919091-61-5
Formula: C₁₉H₁₃Cl₄NO
Molecular Weight:413.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(E,E)-RAMB4 Chemical Structure

CAS No.: 919091-61-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(E,E)-RAMB4 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1^[1].

IC₅₀ & Target

PTP1B^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	4.1 μM Compound: 4b	Cytotoxicity against Mus musculus (mouse) B16 cells assessed as growth inhibition after 72 hr by MTT assay Cytotoxicity against Mus musculus (mouse) B16 cells assessed as growth inhibition after 72 hr by MTT assay	10.1007/s00044-013-0557-9
CCRF-CEM	IC₅₀	0.81 μM Compound: 408	Antiproliferative activity against human CEM cells assessed as cell growth inhibition Antiproliferative activity against human CEM cells assessed as cell growth inhibition	[PMID: 32172081]
CCRF-CEM	IC₅₀	20.8 μM Compound: 1c	Cytotoxicity against CEM T-lymphocytes. Cytotoxicity against CEM T-lymphocytes.	[PMID: 11170648]
Jurkat	IC₅₀	3.09 μM Compound: 1c	Cytotoxicity against human Jurkat T cells. Cytotoxicity against human Jurkat T cells.	[PMID: 11170648]
L1210	IC₅₀	0.81 μM Compound: 408	Antiproliferative activity against mouse L1210 cells assessed as cell growth inhibition Antiproliferative activity against mouse L1210 cells assessed as cell growth inhibition	[PMID: 32172081]
L1210	IC₅₀	129 μM Compound: 1c	Cytotoxicity against murine L1210 cells. Cytotoxicity against murine L1210 cells.	[PMID: 11170648]
L1210	IC₅₀	3.6 μM Compound: 4b	Cytotoxicity against Mus musculus (mouse) L1210 cells assessed as growth inhibition after 72 hr by MTT assay Cytotoxicity against Mus musculus (mouse) L1210 cells assessed as growth inhibition after 72 hr by MTT assay	10.1007/s00044-013-0557-9
P388	IC₅₀	0.81 μM Compound: 408	Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition	[PMID: 32172081]
P388	IC₅₀	1.01 μM Compound: 1c	Cytotoxicity against murine P388 cells. Cytotoxicity against murine P388 cells.	[PMID: 11170648]

Chemical Information

CAS No. 919091-61-5
Molecular Weight 413.12
Formula C₁₉H₁₃Cl₄NO
SMILES

O=C1/C(CNC/C1=C\C2=CC=C(Cl)C(Cl)=C2)=C/C3=CC=C(Cl)C(Cl)=C3.[(E)].[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin, Yongsheng, et al. 3,5-diaryl-ylidene piperidone derivatives and application thereof in preparing blood glucose-reducing and fat-reducing medicine. CN103626692A.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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