RAMB4
Based on 1 publication(s) in Google Scholar
RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity.
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- Pureza : 98.02%
- No. CAS: 145888-79-5
- Fòrmula: C19H13Cl4NO
- Peso molecular:413.12
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) RAMB4
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
4.1 μM
Compound: 4b
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Cytotoxicity against Mus musculus (mouse) B16 cells assessed as growth inhibition after 72 hr by MTT assay
Cytotoxicity against Mus musculus (mouse) B16 cells assessed as growth inhibition after 72 hr by MTT assay
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10.1007/s00044-013-0557-9 |
| CCRF-CEM | IC50 |
0.81 μM
Compound: 408
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Antiproliferative activity against human CEM cells assessed as cell growth inhibition
Antiproliferative activity against human CEM cells assessed as cell growth inhibition
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[PMID: 32172081] |
| CCRF-CEM | IC50 |
20.8 μM
Compound: 1c
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Cytotoxicity against CEM T-lymphocytes.
Cytotoxicity against CEM T-lymphocytes.
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[PMID: 11170648] |
| Jurkat | IC50 |
3.09 μM
Compound: 1c
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Cytotoxicity against human Jurkat T cells.
Cytotoxicity against human Jurkat T cells.
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[PMID: 11170648] |
| L1210 | IC50 |
0.81 μM
Compound: 408
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Antiproliferative activity against mouse L1210 cells assessed as cell growth inhibition
Antiproliferative activity against mouse L1210 cells assessed as cell growth inhibition
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[PMID: 32172081] |
| L1210 | IC50 |
129 μM
Compound: 1c
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Cytotoxicity against murine L1210 cells.
Cytotoxicity against murine L1210 cells.
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[PMID: 11170648] |
| L1210 | IC50 |
3.6 μM
Compound: 4b
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Cytotoxicity against Mus musculus (mouse) L1210 cells assessed as growth inhibition after 72 hr by MTT assay
Cytotoxicity against Mus musculus (mouse) L1210 cells assessed as growth inhibition after 72 hr by MTT assay
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10.1007/s00044-013-0557-9 |
| P388 | IC50 |
0.81 μM
Compound: 408
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Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition
Antiproliferative activity against mouse P388 cells assessed as cell growth inhibition
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[PMID: 32172081] |
| P388 | IC50 |
1.01 μM
Compound: 1c
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Cytotoxicity against murine P388 cells.
Cytotoxicity against murine P388 cells.
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[PMID: 11170648] |
In Vitro
RAMB4 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively[1].
RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:Keratinocytes, SiHa, CaSki and ME180 cells
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Concentration:5, 10, 15, 20, 25, 30 µM
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Incubation Time:48 hours
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Result:Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
Chemical Information
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No. CAS 145888-79-5
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Appearance Solid
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Peso molecular 413.12
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Fòrmula C19H13Cl4NO
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Color Light yellow to yellow
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SMILES
O=C(/C(CNC/1)=C/C2=CC=C(Cl)C(Cl)=C2)C1=C\C3=CC(Cl)=C(C=C3)Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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EBioMedicine
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. [Abstract]2023 Feb:88:104444. PMID: 36709580
Solvente y solubilidad
In Vitro:
DMSO : 5 mg/mL (12.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4206 mL | 12.1030 mL | 24.2060 mL | 60.5151 mL |
| 5 mM | 0.4841 mL | 2.4206 mL | 4.8412 mL | 12.1030 mL | |
| 10 mM | 0.2421 mL | 1.2103 mL | 2.4206 mL | 6.0515 mL |
RAMB4 Related Classifications
HY-W054146 Related Classifications
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