1. Metabolic Enzyme/Protease
  2. Proteasome
  3. PTP1B-IN-9

PTP1B-IN-9 

Cat. No.: HY-W054146
Handling Instructions

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity.

For research use only. We do not sell to patients.

PTP1B-IN-9 Chemical Structure

PTP1B-IN-9 Chemical Structure

CAS No. : 145888-79-5

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Description

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].

In Vitro

PTP1B-IN-9 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively[1].
PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM[1].

Cell Viability Assay[1]

Cell Line: Keratinocytes, SiHa, CaSki and ME180 cells
Concentration: 5, 10, 15, 20, 25, 30 µM
Incubation Time: 48 hours
Result: Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
Molecular Weight

413.12

Formula

C₁₉H₁₃Cl₄NO

CAS No.

145888-79-5

SMILES

O=C(/C(CNC/1)=C/C2=CC=C(Cl)C(Cl)=C2)C1=C\C3=CC(Cl)=C(C=C3)Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PTP1B-IN-9ProteasomeUbiquitinproteasomedegradationstressresponsecervicalcancerHeLacellsInhibitorinhibitorinhibit

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