1. Metabolic Enzyme/Protease
  2. Proteasome
  3. PTP1B-IN-9

PTP1B-IN-9 

Cat. No.: HY-W054146 Purity: 98.43%
Handling Instructions

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity.

For research use only. We do not sell to patients.

PTP1B-IN-9 Chemical Structure

PTP1B-IN-9 Chemical Structure

CAS No. : 145888-79-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].

In Vitro

PTP1B-IN-9 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively[1].
PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Keratinocytes, SiHa, CaSki and ME180 cells
Concentration: 5, 10, 15, 20, 25, 30 µM
Incubation Time: 48 hours
Result: Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
Molecular Weight

413.12

Formula

C₁₉H₁₃Cl₄NO

CAS No.

145888-79-5

SMILES

O=C(/C(CNC/1)=C/C2=CC=C(Cl)C(Cl)=C2)C1=C\C3=CC(Cl)=C(C=C3)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4206 mL 12.1030 mL 24.2060 mL
5 mM 0.4841 mL 2.4206 mL 4.8412 mL
10 mM 0.2421 mL 1.2103 mL 2.4206 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PTP1B-IN-9ProteasomeUbiquitinproteasomedegradationstressresponsecervicalcancerHeLacellsInhibitorinhibitorinhibit

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PTP1B-IN-9
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