2375455-53-9
Chemical Structure
RAJQ14
- CAS No.: 2375455-53-9
- Formula:C60H64Cl5N9O4S
- Molecular Weight:1184.54
InChIKey: QDMXTAFOEZOVJS-LHTBMSQMSA-N
SMILES: O=C(NCCCN1CCN(CCCCCCOC2=CC=C(C[C@H](N)C(N3C/C(C(/C(C3)=C\C4=CC=C(Cl)C(Cl)=C4)=O)=C/C5=CC=C(Cl)C(Cl)=C5)=O)C=C2)CC1)C[C@H]6C7=NN=C(C)N7C8=C(C(C)=C(C)S8)C(C9=CC=C(Cl)C=C9)=N6
Biological Activity: RAJQ14 is a BRD4 PROTAC-like CAP-TAC (Proteasome Cap Targeting Chimeras) degrader. RAJQ14 binds to 19S proteasome cap subunits RPN1, RPN10, RPN13, and USP14 to recruit target proteins to the proteasome for ubiquitination-independent, proteasome-dependent degradation. RAJQ14 can be used for the research of cancer[1] (Pink: BRD4 Ligand (HY-181496); Blue: Proteasome Ligand (HY-128978); Black: Linker).
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RAJQ14 | RAJQ14 is a BRD4 PROTAC-like CAP-TAC (Proteasome Cap Targeting Chimeras) degrader. RAJQ14 binds to 19S proteasome cap subunits RPN1, RPN10, RPN13, and USP14 to recruit target proteins to the proteasome for ubiquitination-independent, proteasome-dependent degradation. RAJQ14 can be used for the research of cancer (Pink: BRD4 Ligand (HY-181496); Blue: Proteasome Ligand (HY-128978); Black: Linker). | |||||||||||||||||||||
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