1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. CNQX disodium

CNQX disodium  (Synonyms: FG9065 disodium)

Cat. No.: HY-15066A Purity: 99.73%
COA Handling Instructions

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist. CNQX disodium blocks the expression of fear-potentiated startle in rats.

For research use only. We do not sell to patients.

CNQX disodium Chemical Structure

CNQX disodium Chemical Structure

CAS No. : 479347-85-8

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Based on 9 publication(s) in Google Scholar

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Description

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5].

IC50 & Target

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)[1]

In Vitro

CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval[4].
The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 180-200 g[4]
Dosage: 0.75, 1.5, and 3 mg/kg
Administration: IP; 20 min before testing
Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.
Molecular Weight

276.12

Formula

C9H2N4Na2O4

CAS No.
Appearance

Solid

Color

Brown to red

SMILES

N#CC1=CC2=C([N-]C(C([N-]2)=O)=O)C=C1[N+]([O-])=O.[Na+].[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10.53 mg/mL (38.14 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6216 mL 18.1081 mL 36.2161 mL
5 mM 0.7243 mL 3.6216 mL 7.2432 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6216 mL 18.1081 mL 36.2161 mL 90.5403 mL
5 mM 0.7243 mL 3.6216 mL 7.2432 mL 18.1081 mL
10 mM 0.3622 mL 1.8108 mL 3.6216 mL 9.0540 mL
15 mM 0.2414 mL 1.2072 mL 2.4144 mL 6.0360 mL
20 mM 0.1811 mL 0.9054 mL 1.8108 mL 4.5270 mL
25 mM 0.1449 mL 0.7243 mL 1.4486 mL 3.6216 mL
30 mM 0.1207 mL 0.6036 mL 1.2072 mL 3.0180 mL
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CNQX disodium
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HY-15066A
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