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  3. CNQX disodium

CNQX disodium (Synonyms: FG9065 disodium)

Cat. No.: HY-15066A
Handling Instructions

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist. CNQX disodium blocks the expression of fear-potentiated startle in rats.

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CNQX disodium Chemical Structure

CNQX disodium Chemical Structure

CAS No. : 479347-85-8

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Description

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5].

IC50 & Target

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)[1]

In Vitro

CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

In Vivo

CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval[4].
The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg[5].

Animal Model: Male Wistar rats weighing 180-200 g[4]
Dosage: 0.75, 1.5, and 3 mg/kg
Administration: IP; 20 min before testing
Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.
Molecular Weight

276.12

Formula

C₉H₂N₄Na₂O₄

CAS No.

479347-85-8

SMILES

N#CC1=CC2=C([N-]C(C([N-]2)=O)=O)C=C1[N+]([O-])=O.[Na+].[Na+]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CNQX disodiumFG9065 disodiumiGluRIonotropic glutamate receptorsAMPAkainatenon-NMDAfear-potentiatedstartleInhibitorinhibitorinhibit

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CNQX disodium
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