479347-85-8
479347-85-8
Chemical Structure
CNQX disodium
Synonym(s): FG9065 disodium
- CAS No.: 479347-85-8
- Formula:C9H2N4Na2O4
- Molecular Weight:276.12
IUPAC Name: sodium 6-cyano-7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-1,4-diide
InChIKey: MKXVAOBJYRHKGY-UHFFFAOYSA-L
SMILES: N#CC1=CC2=C([N-]C(C([N-]2)=O)=O)C=C1[N+]([O-])=O.[Na+].[Na+]
Biological Activity: CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5].
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CNQX disodium | 99.95% | CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist. CNQX disodium blocks the expression of fear-potentiated startle in rats. | ||||||||||||||||||||
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References
- [1]. T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241(4866):701-3. [Content Brief]
- [5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8. [Content Brief]
Keywords
