1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. YM90K

YM90K 

Cat. No.: HY-15071
Handling Instructions

YM90K is a potent and selective AMPA receptor antagonist with a Ki of 84 nM. YM90K is less potent in inhibiting kainate (Ki of 2.2 μM) and NMDA (Ki of 37 μM) receptors. YM90K has neuroprotective actions.

For research use only. We do not sell to patients.

YM90K Chemical Structure

YM90K Chemical Structure

CAS No. : 154164-30-4

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Description

YM90K is a potent and selective AMPA receptor antagonist with a Ki of 84 nM. YM90K is less potent in inhibiting kainate (Ki of 2.2 μM) and NMDA (Ki of 37 μM) receptors. YM90K has neuroprotective actions[1].

IC50 & Target

Ki: 84 nM (AMPA receptor), 2.2 μM (Kainate receptor) and 37 μM (NMDA receptor)[1]

In Vitro

YM90K (30 nmol) co-injected with AMPA or kainate into the rat striatum protected cholinergic neurons against AMPA- or kainate-induced neurotoxicity[1].

In Vivo

YM90K showes potent suppressive activity against audiogenic seizure in DBA/2 mice; ED50 values of YM90K against tonic seizure is 2.54 mg/kg (i.p.). The duration of the anticonvulsant effects of YM90K is 30 min[1].
In a global ischemia model, YM90K (15 mg/kg i.p. x 3) significantly prevents the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. The therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p. x 3) is 6 h[1].
In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduces the volume of ischemic damage in the cerebral cortex in F344 rats[1].

Molecular Weight

309.67

Formula

C₁₁H₈ClN₅O₄

CAS No.

154164-30-4

SMILES

O=C1NC2=C(C=C(N3C=CN=C3)C([N+]([O-])=O)=C2)NC1=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

YM90KiGluRIonotropic glutamate receptorsAMPAneuroprotectiveanticonvulsantischemiaInhibitorinhibitorinhibit

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YM90K
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HY-15071
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