Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists

  • Science. 1988 Aug 5;241(4866):701-3. doi: 10.1126/science.2899909.
T Honoré  1 ,  S N Davies ,  J Drejer ,  E J Fletcher ,  P Jacobsen ,  D Lodge ,  F E Nielsen
Affiliations
  • 1. Ferroson Research Division, Soeborg, Denmark.
PMID: 2899909 DOI: 10.1126/science.2899909
Abstract

The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.

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