2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. DNQX disodium salt

DNQX disodium salt  (Synonyms: FG 9041 disodium salt)

Cat. No.: HY-103233 Purity: 98.07%
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Handling Instructions Technical Support

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).

For research use only. We do not sell to patients.

DNQX disodium salt

DNQX disodium salt Chemical Structure

CAS No. : 1312992-24-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of DNQX disodium salt:

DNQX disodium salt Related Antibodies

Top Publications Citing Use of Products

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AMPA Receptor NMDA Receptor Kainate Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].

IC50 & Target

AMPA Receptor

 

Kainate Receptor

 

In Vitro

DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DNQX disodium salt Related Antibodies
In Vivo

DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

296.10

Formula

C8H2N4Na2O6
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

[O-][N+](C1=CC(N=C2O[Na])=C(C=C1[N+]([O-])=O)N=C2O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (168.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 3.33 mg/mL (11.25 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3772 mL 16.8862 mL 33.7724 mL
5 mM 0.6754 mL 3.3772 mL 6.7545 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.3772 mL 16.8862 mL 33.7724 mL 84.4309 mL
5 mM 0.6754 mL 3.3772 mL 6.7545 mL 16.8862 mL
10 mM 0.3377 mL 1.6886 mL 3.3772 mL 8.4431 mL
DMSO 15 mM 0.2251 mL 1.1257 mL 2.2515 mL 5.6287 mL
20 mM 0.1689 mL 0.8443 mL 1.6886 mL 4.2215 mL
25 mM 0.1351 mL 0.6754 mL 1.3509 mL 3.3772 mL
30 mM 0.1126 mL 0.5629 mL 1.1257 mL 2.8144 mL
40 mM 0.0844 mL 0.4222 mL 0.8443 mL 2.1108 mL
50 mM 0.0675 mL 0.3377 mL 0.6754 mL 1.6886 mL
60 mM 0.0563 mL 0.2814 mL 0.5629 mL 1.4072 mL
80 mM 0.0422 mL 0.2111 mL 0.4222 mL 1.0554 mL
100 mM 0.0338 mL 0.1689 mL 0.3377 mL 0.8443 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DNQX disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNQX disodium1312992-24-7FG 9041 disodiumiGluRIonotropic glutamate receptorscompetitiveselectivenon-NMDAthalamicreticularnucleusquinoxalineInhibitorinhibitorinhibit

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