1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. DNQX disodium salt

DNQX disodium salt (Synonyms: FG 9041 disodium salt)

Cat. No.: HY-103233
Handling Instructions

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).

For research use only. We do not sell to patients.

DNQX disodium salt Chemical Structure

DNQX disodium salt Chemical Structure

CAS No. : 1312992-24-7

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Description

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].

IC50 & Target

Non-NMDA Receptor[1]

In Vitro

DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

300.14

Formula

C₈H₆N₄Na₂O₆

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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DNQX disodium salt
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HY-103233
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