1. Membrane Transporter/Ion Channel Neuronal Signaling
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  3. DNQX disodium salt

DNQX disodium salt  (Synonyms: FG 9041 disodium salt)

Cat. No.: HY-103233
Handling Instructions

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).

For research use only. We do not sell to patients.

DNQX disodium salt Chemical Structure

DNQX disodium salt Chemical Structure

CAS No. : 1312992-24-7

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Description

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].

IC50 & Target

Non-NMDA Receptor[1]

In Vitro

DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

300.14

Formula

C8H6N4Na2O6

CAS No.
SMILES

O=[N+](C1=CC2=C(C=C1[N+]([O-])=O)NC(O[Na])C(O[Na])N2)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DNQX disodium salt
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HY-103233
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