DNQX disodium salt
Based on 11 publication(s) in Google Scholar
DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 1312992-24-7
- Formula: C8H2N4Na2O6
- Molecular Weight:296.10
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) DNQX disodium salt
More- Nat Commun. 2024 Sep 1;15(1):7603. [Abstract]
- Plant Biotechnol J. 2025 Nov 14. [Abstract]
- Cell Death Discov. 2020 Sep 17;6:87. [Abstract]
- Neural Regen Res. 2022 Jan;17(1):178-184. [Abstract]
- Transl Psychiatry. 2026 Mar 27;16(1):210. [Abstract]
- Transl Psychiatry. 2025 Aug 28;15(1):325. [Abstract]
- Life Sci. 2024 Dec 3:123290. [Abstract]
- Int J Mol Sci. 2025 Mar 23;26(7):2909. [Abstract]
- J Physiol. 2023 Aug;601(16):3585-3604. [Abstract]
- J Psychiatr Res. 2023 Jul:163:180-194. [Abstract]
- Am J Physiol Endocrinol Metab. 2025 Mar 24. [Abstract]
All iGluR Isoforms
More
Biological Activity
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AMPA Receptor |
Kainate Receptor |
DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1312992-24-7
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Appearance Solid
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Molecular Weight 296.10
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Formula C8H2N4Na2O6
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Color Pink to red
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SMILES
[O-][N+](C1=CC(N=C2O[Na])=C(C=C1[N+]([O-])=O)N=C2O[Na])=O
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Synonyms
FG 9041 disodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (11)
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Journal Impact Factor
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Most Recent
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Nat Commun
2024 Sep 1;15(1):7603. PMID: 39217143 -
Plant Biotechnol J
Join the Green and Sustainable Team: Magnesium Oxide Nanoparticles Boost Broad-Spectrum Viral Resistance in Solanaceae Plants. [Abstract]2025 Nov 14. PMID: 41235714 -
Cell Death Discov
2020 Sep 17;6:87. PMID: 33014431 -
Neural Regen Res
2022 Jan;17(1):178-184. PMID: 34100454 -
Transl Psychiatry
2026 Mar 27;16(1):210. PMID: 41888094 -
Transl Psychiatry
Activation of the supramammillary-dentate gyrus circuit enhances alertness and cognitive function in a rat model of ADHD. [Abstract]2025 Aug 28;15(1):325. PMID: 40877238 -
Life Sci
The modulation of cholecystokinin receptor 1 in the NAc core input from VTA on METH-induced CPP acquisition. [Abstract]2024 Dec 3:123290. PMID: 39638282 -
Int J Mol Sci
The E3 Ubiquitin Ligase PRAJA1: A Key Regulator of Synaptic Dynamics and Memory Processes with Implications for Alzheimer's Disease. [Abstract]2025 Mar 23;26(7):2909. PMID: 40243483 -
J Physiol
Orexin recruits non-selective cationic conductance and endocannabinoid to dynamically modulate firing of caudal pontine reticular nuclear neurones. [Abstract]2023 Aug;601(16):3585-3604. PMID: 37421377 -
J Psychiatr Res
Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing. [Abstract]2023 Jul:163:180-194. PMID: 37216772 -
Am J Physiol Endocrinol Metab
GLP-1 receptor agonist exendin-4 suppresses food intake by inhibiting hindbrain orexigenic NPY neurons. [Abstract]2025 Mar 24. PMID: 40126941
Solvent & Solubility
DMSO : 50 mg/mL (168.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 3.33 mg/mL (11.25 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Honoré T, et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 1988;241(4866):701-703. [Content Brief]
[2]. Lee SH, et al. Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J Neurophysiol. 2010;103(4):1728-1734. [Content Brief]
[3]. Sharp JW, et al. DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex. Brain Res. 1995;687(1-2):114-124. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.3772 mL | 16.8862 mL | 33.7724 mL | 84.4309 mL |
| 5 mM | 0.6754 mL | 3.3772 mL | 6.7545 mL | 16.8862 mL | |
| 10 mM | 0.3377 mL | 1.6886 mL | 3.3772 mL | 8.4431 mL | |
| DMSO | 15 mM | 0.2251 mL | 1.1257 mL | 2.2515 mL | 5.6287 mL |
| 20 mM | 0.1689 mL | 0.8443 mL | 1.6886 mL | 4.2215 mL | |
| 25 mM | 0.1351 mL | 0.6754 mL | 1.3509 mL | 3.3772 mL | |
| 30 mM | 0.1126 mL | 0.5629 mL | 1.1257 mL | 2.8144 mL | |
| 40 mM | 0.0844 mL | 0.4222 mL | 0.8443 mL | 2.1108 mL | |
| 50 mM | 0.0675 mL | 0.3377 mL | 0.6754 mL | 1.6886 mL | |
| 60 mM | 0.0563 mL | 0.2814 mL | 0.5629 mL | 1.4072 mL | |
| 80 mM | 0.0422 mL | 0.2111 mL | 0.4222 mL | 1.0554 mL | |
| 100 mM | 0.0338 mL | 0.1689 mL | 0.3377 mL | 0.8443 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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