115066-14-3
115066-14-3
Chemical Structure
CNQX
Synonym(s): FG9065
- CAS No.: 115066-14-3
- Formula:C9H4N4O4
- Molecular Weight:232.15
IUPAC Name: 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile
InChIKey: RPXVIAFEQBNEAX-UHFFFAOYSA-N
SMILES: O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O
Biological Activity: CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5].
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CNQX | 99.38% | CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats. | ||||||||||||||||||||
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CNQX (Standard) | ≥98% | CNQX (Standard) is the analytical standard of CNQX. This product is intended for research and analytical applications. CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats. | ||||||||||||||||||||
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References
- [1]. T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241(4866):701-3. [Content Brief]
- [5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8. [Content Brief]
