1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Cycloleucine

Cycloleucine 

Cat. No.: HY-30008 Purity: >98.0%
Handling Instructions

Cycloleucine is a specific and reversible inhibitor of nucleic acid methylations. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine has anxiolytic and cytostatic effects.

For research use only. We do not sell to patients.

Cycloleucine Chemical Structure

Cycloleucine Chemical Structure

CAS No. : 52-52-8

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cycloleucine is a specific and reversible inhibitor of nucleic acid methylations. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine has anxiolytic and cytostatic effects[1][2][3][5].

IC50 & Target

Ki: 600 μM (NMDA)[1][2]

In Vitro

Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts[4].
Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%[4].
Cytostatic (10 µg/mL) inhibits the viability human KB and mouse L1210s leukemia cell lines[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cycloleucine (0.5-4 µg; intracerebroventrical injection) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats bilaterally cannulated into the nucleus accumbens septi (NAS)[3]
Dosage: 1 µL of 0.5, 1.0, 2.0, 4 µg/µL
Administration: Intracerebroventrical injection
Result: Increased time spent in the open arms and extreme arrivals at all doses. Increased open arm entries at the dose of 4 μg.
Molecular Weight

129.16

Formula

C₆H₁₁NO₂

CAS No.

52-52-8

SMILES

O=C(O)C1(CCCC1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >98.0%

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Keywords:

CycloleucineiGluRIonotropic glutamate receptorsnucleicmethylationsATPtransferaseNMDAglycineanxiolyticcytostaticInhibitorinhibitorinhibit

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Cycloleucine
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HY-30008
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