52-52-8
52-52-8
Chemical Structure
Cycloleucine
- CAS 番号: 52-52-8
- Formula:C6H11NO2
- Molecular Weight:129.16
IUPAC Name: 1-aminocyclopentane-1-carboxylic acid
InChIKey: NILQLFBWTXNUOE-UHFFFAOYSA-N
SMILES: O=C(O)C1(CCCC1)N
Biological Activity: Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects[1][2][3][4].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Cycloleucine | 98.0% | Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine is antagonist of NMDA receptor associated glycine receptor, with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro. Cycloleucine has anxiolytic and cytostatic effects. | ||||||||||||||||||||
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(1S,3R)-ACPD | (1S,3R)-ACPD is a mGluR agonist that can depolarize pyramidal cells. | |||||||||||||||||||||
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BCH (Standard) | 99.84% | BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. | ||||||||||||||||||||
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trans-ACPD | 98.0% | trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons. | ||||||||||||||||||||
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cis-ACPD | cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively. | |||||||||||||||||||||
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1-Aminocyclopropane-1-carboxylic acid | 98.0% | 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate, 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally, 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors, inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex, but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity.. | ||||||||||||||||||||
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1-Aminocyclobutanecarboxylic acid | 98.0% | 1-Aminocyclobutanecarboxylic acid is a cyclobutane-type amino acid that acts as a substrate analog of enzymes related to plant ethylene synthesis. | ||||||||||||||||||||
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(R)-2-amino-2-cyclopentylacetic acid | 98.0% | (R)-2-amino-2-cyclopentylacetic acid is a Glycine (HY-Y0966) derivative. | ||||||||||||||||||||
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(S)-2-Methylpyrrolidine-2-carboxylic acid | 98.0% | (S)-2-Methylpyrrolidine-2-carboxylic acid is a proline derivative. | ||||||||||||||||||||
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H-Cyclopentyl-Gly-OH | 98.0% | H-Cyclopentyl-Gly-OH is a Glycine (HY-Y0966) derivative. | ||||||||||||||||||||
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2-Amino-2-cyclopentylacetic acid | 97.0% | 2-Amino-2-cyclopentylacetic acid is a Glycine (HY-Y0966) derivative. | ||||||||||||||||||||
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References
- [1]. Hood WF, et, al. 1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor. Eur J Pharmacol. 1989 Feb 28;161(2-3):281-2. [Content Brief]
- [2]. Caboche M, et, al. RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation. Eur J Biochem. 1977 Mar 15;74(1):19-29. [Content Brief]
- [3]. Gargiulo API, et, al. Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats. Neuropsychobiology. 2020;79(3):191-197. [Content Brief]
- [4]. Duś D, et, al. Cytostatic activity in vitro of cycloleucine, aspartic acid and glutamic acid phosphonic analogues. Arch Immunol Ther Exp (Warsz). 1980;28(3):433-8. [Content Brief]
