1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    GPCR/G Protein
  2. iGluR
    mGluR
  3. cis-ACPD

cis-ACPD 

Cat. No.: HY-19434A
Handling Instructions

cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. And it is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively.

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cis-ACPD Chemical Structure

cis-ACPD Chemical Structure

CAS No. : 477331-06-9

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Description

cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. And it is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].

IC50 & Target[1][2]

NMDA

3.3 μM (IC50)

mGluR2

13 μM (EC50)

mGluR4

50 μM (EC50)

In Vitro

cis-ACPD is a selective group II mGluR agonist, with EC50s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively[2].
cis-ACPD (1-1000 µM; 60 min) stimulates hydrolysis of 3H-phosphoinositide[1].

In Vivo

cis-ACPD (1-1000 mg/kg; i.p.) produces dose-related convulsions in rats[1].

Molecular Weight

173.17

Formula

C₇H₁₁NO₄

CAS No.

477331-06-9

SMILES

O=C([[email protected]]1(N)C[[email protected]](C(O)=O)CC1)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

cis-ACPDiGluRmGluRIonotropic glutamate receptorsMetabotropic glutamate receptorsNMDAreceptorgroupIImGluR2mGluR4convulsionsInhibitorinhibitorinhibit

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cis-ACPD
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