(1S,3R)-ACPD
(1S,3R)-ACPD is a mGluR agonist that can depolarize pyramidal cells.
For research use only. We do not sell to patients.
- CAS No.: 111900-32-4
- Formula: C7H11NO4
- Molecular Weight:173.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
15 μM
Compound: (+/-)5
|
Activity tested at cloned rat Metabotropic glutamate receptor 1 expressed in Chinese Hamster Ovary (CHO) cells
Activity tested at cloned rat Metabotropic glutamate receptor 1 expressed in Chinese Hamster Ovary (CHO) cells
|
[PMID: 12825948] |
| CHO | EC50 |
2 μM
Compound: (+/-)5
|
Activity tested at cloned rat mGluR2 receptor expressed in Chinese Hamster Ovary (CHO) cells
Activity tested at cloned rat mGluR2 receptor expressed in Chinese Hamster Ovary (CHO) cells
|
[PMID: 12825948] |
| CHO | EC50 |
23 μM
Compound: (+/-)5
|
Activity tested at cloned rat Metabotropic glutamate receptor 5 expressed in Chinese Hamster Ovary (CHO) cells
Activity tested at cloned rat Metabotropic glutamate receptor 5 expressed in Chinese Hamster Ovary (CHO) cells
|
[PMID: 12825948] |
| CHO | EC50 |
800 μM
Compound: (+/-)5
|
Activity tested at cloned rat Metabotropic glutamate receptor 4 expressed in Chinese Hamster Ovary (CHO) cells
Activity tested at cloned rat Metabotropic glutamate receptor 4 expressed in Chinese Hamster Ovary (CHO) cells
|
[PMID: 12825948] |
| HEK293 | EC50 |
>100 μM
Compound: 16
|
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
|
[PMID: 15801843] |
| HEK293 | EC50 |
18 μM
Compound: 1/ (1S,3R -)-ACPD
|
Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
|
[PMID: 9301676] |
| HEK293 | EC50 |
9.3 μM
Compound: 1/ (1S,3R -)-ACPD
|
Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
|
[PMID: 9301676] |
| HEK293 | EC50 |
>1000 μM
Compound: 1/ (1S,3R -)-ACPD
|
Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
|
[PMID: 9301676] |
Chemical Information
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CAS No. 111900-32-4
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Molecular Weight 173.17
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Formula C7H11NO4
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SMILES
O=C([C@@]1(N)C[C@H](C(O)=O)CC1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)