(1S,3R)-ACPD

Cat. No.: HY-100823: Data Sheet
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(1S,3R)-ACPD is a mGluR agonist that can depolarize pyramidal cells.

For research use only. We do not sell to patients.

(1S,3R)-ACPD Chemical Structure

CAS No. : 111900-32-4

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Other Forms of (1S,3R)-ACPD:

trans-ACPD In-stock
cis-ACPD Get quote

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
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Description

(1S,3R)-ACPD is a mGluR agonist that can depolarize pyramidal cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	15 μM Compound: (+/-)5	Activity tested at cloned rat Metabotropic glutamate receptor 1 expressed in Chinese Hamster Ovary (CHO) cells Activity tested at cloned rat Metabotropic glutamate receptor 1 expressed in Chinese Hamster Ovary (CHO) cells	[PMID: 12825948]
CHO	EC₅₀	2 μM Compound: (+/-)5	Activity tested at cloned rat mGluR2 receptor expressed in Chinese Hamster Ovary (CHO) cells Activity tested at cloned rat mGluR2 receptor expressed in Chinese Hamster Ovary (CHO) cells	[PMID: 12825948]
CHO	EC₅₀	23 μM Compound: (+/-)5	Activity tested at cloned rat Metabotropic glutamate receptor 5 expressed in Chinese Hamster Ovary (CHO) cells Activity tested at cloned rat Metabotropic glutamate receptor 5 expressed in Chinese Hamster Ovary (CHO) cells	[PMID: 12825948]
CHO	EC₅₀	800 μM Compound: (+/-)5	Activity tested at cloned rat Metabotropic glutamate receptor 4 expressed in Chinese Hamster Ovary (CHO) cells Activity tested at cloned rat Metabotropic glutamate receptor 4 expressed in Chinese Hamster Ovary (CHO) cells	[PMID: 12825948]
HEK293	EC₅₀	18 μM Compound: 1/ (1S,3R -)-ACPD	Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation	[PMID: 9301676]
HEK293	EC₅₀	9.3 μM Compound: 1/ (1S,3R -)-ACPD	Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation	[PMID: 9301676]
HEK293	EC₅₀	> 100 μM Compound: 16	Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive	[PMID: 15801843]
HEK293	EC₅₀	> 1000 μM Compound: 1/ (1S,3R -)-ACPD	Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation	[PMID: 9301676]

Molecular Weight

173.17

Formula

C₇H₁₁NO₄

CAS No.

111900-32-4

SMILES

O=C([C@@]1(N)C[C@H](C(O)=O)CC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (267 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. A E Bandrowski, et al. Metabotropic glutamate receptors modify ionotropic glutamate responses in neocortical pyramidal cells and interneurons. Exp Brain Res. 2001 Jan;136(1):25-40. [Content Brief]

(1S,3R)-ACPD Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1S,3R)-ACPD111900-32-4mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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