477331-06-9
477331-06-9
Chemical Structure
cis-ACPD
- CAS No.: 477331-06-9
- Formula:C7H11NO4
- Molecular Weight:173.17
IUPAC Name: (1R,3R)-1-aminocyclopentane-1,3-dicarboxylic acid
InChIKey: YFYNOWXBIBKGHB-CLZZGJSISA-N
SMILES: O=C([C@]1(N)C[C@H](C(O)=O)CC1)O
Biological Activity: cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].
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cis-ACPD | cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively. | |||||||||||||||||||||
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References
- [1]. Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56(5):1789-96. [Content Brief]
- [2]. Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57(11): 889-95. [Content Brief]
Keywords
