1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
    Potassium Channel
  3. Ifenprodil tartrate

Ifenprodil tartrate 

Cat. No.: HY-12882A Purity: 98.87%
Handling Instructions

Ifenprodil tartrate is the atypical N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits NMDA-induced currents at NR1A/NR2B receptors with high affinity (IC50 = 0.34 μM). Ifenprodil tartrate inhibits G protein-activated inwardly rectifying K+ channels (GIRK, also known as Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil, which is a clinically used cerebral vasodilator, interacts with several receptors, such as alpha1 adrenergic, N-methyl-D-aspartate, serotonin and sigma receptors.

For research use only. We do not sell to patients.

Ifenprodil tartrate Chemical Structure

Ifenprodil tartrate Chemical Structure

CAS No. : 23210-58-4

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10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
50 mg USD 84 In-stock
Estimated Time of Arrival: December 31
100 mg USD 144 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ifenprodil tartrate is the atypical N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits NMDA-induced currents at NR1A/NR2B receptors with high affinity (IC50 = 0.34 μM)[1]. Ifenprodil tartrate inhibits G protein-activated inwardly rectifying K+ channels (GIRK, also known as Kir3), reduces inward currents through the basal GIRK activity[2]. Ifenprodil, which is a clinically used cerebral vasodilator, interacts with several receptors, such as alpha1 adrenergic, N-methyl-D-aspartate, serotonin and sigma receptors[2].

IC50 & Target

IC50: 0.34 μM (NR1A/NR2B receptor)[1]

Clinical Trial
Molecular Weight

400.49

Formula

C₂₁H₂₇NO₂ . ₁/₂C₄H₆O₆

CAS No.

23210-58-4

SMILES

OC(C1=CC=C(O)C=C1)C(C)N(CC2)CCC2CC3=CC=CC=C3.O=C(O)[[email protected]](O)[[email protected]@H](O)C(O)=O.OC(C4=CC=C(O)C=C4)C(C)N(CC5)CCC5CC6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 500 mg/mL (1248.47 mM)

H2O : 5 mg/mL (12.48 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4969 mL 12.4847 mL 24.9694 mL
5 mM 0.4994 mL 2.4969 mL 4.9939 mL
10 mM 0.2497 mL 1.2485 mL 2.4969 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  1% DMSO   99% saline

    Solubility: ≥ 1 mg/mL (2.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.87%

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Keywords:

IfenprodiliGluRPotassium ChannelIonotropic glutamate receptorsKcsAInhibitorinhibitorinhibit

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Ifenprodil tartrate
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HY-12882A
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