1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Ro 25-6981 Maleate

Ro 25-6981 Maleate 

Cat. No.: HY-13993A Purity: 98.22%
Handling Instructions

Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD).

For research use only. We do not sell to patients.

Ro 25-6981 Maleate Chemical Structure

Ro 25-6981 Maleate Chemical Structure

CAS No. : 1312991-76-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 106 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 138 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Ro 25-6981 Maleate:

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  • Biological Activity

  • Purity & Documentation

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Description

Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD)[1][2][3].

In Vivo

Ro 25-6981 Maleate (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1].
Ro 25-6981 Maleate (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 Maleate (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-OHDA-lesioned rats[1]
Dosage: 0.39-12.5 mg/kg
Administration: I.p.
Result: Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound.
Animal Model: Male albino rats of Wistar strain[2]
Dosage: 1, 3 mg/kg
Administration: I.p.
Result: Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development.
Molecular Weight

455.54

Formula

C26H33NO6

CAS No.
SMILES

OC1=CC=C([[email protected]](O)[[email protected]@H](C)CN2CCC(CC3=CC=CC=C3)CC2)C=C1.O=C(O)/C=C\C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.52 mM; Need ultrasonic)

H2O : 8.33 mg/mL (18.29 mM; ultrasonic and warming and heat to 45°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1952 mL 10.9760 mL 21.9520 mL
5 mM 0.4390 mL 2.1952 mL 4.3904 mL
10 mM 0.2195 mL 1.0976 mL 2.1952 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (10.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (10.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (10.98 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.22%

References
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Product Name:
Ro 25-6981 Maleate
Cat. No.:
HY-13993A
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