Ro 25-6981 hydrochloride
Based on 9 publication(s) in Google Scholar
Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD).
For research use only. We do not sell to patients.
- CAS No.: 919289-58-0
- Formula: C22H30ClNO2
- Molecular Weight:375.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ro 25-6981 hydrochloride
More- Cell Death Differ. 2023 Jul;30(7):1726-1741. [Abstract]
- Br J Pharmacol. 2026 Jun;183(11):2857-2873. [Abstract]
- CNS Neurosci Ther. 2023 May;29(5):1229-1242. [Abstract]
- Neurobiol Dis. 2025 Oct 15:215:107090. [Abstract]
- Neurochem Int. 2021 Feb:143:104942. [Abstract]
- Sci Rep. 2022 Oct 12;12(1):17114. [Abstract]
- Neuropharmacology. 2022 Mar 15:206:108947. [Abstract]
- Exp Brain Res. 2023 Dec;241(11-12):2735-2750. [Abstract]
- bioRxiv. 2026 Apr 23.
All iGluR Isoforms
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Biological Activity
Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1].
Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2].
Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-OHDA-lesioned rats[1]
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Dosage:0.39-12.5 mg/kg
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Administration:I.p.
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Result:Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound.
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Animal Model:Male albino rats of Wistar strain[2]
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Dosage:1, 3 mg/kg
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Administration:I.p.
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Result:Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development.
Chemical Information
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CAS No. 919289-58-0
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Molecular Weight 375.93
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Formula C22H30ClNO2
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SMILES
OC1=CC=C([C@H](O)[C@@H](C)CN2CCC(CC3=CC=CC=C3)CC2)C=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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Cell Death Differ
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. [Abstract]2023 Jul;30(7):1726-1741. PMID: 37142655 -
Br J Pharmacol
GW201 mediates neuroprotection via allosteric modulation of NMDA receptor activity in the middle cerebral artery occlusion (MCAO) model. [Abstract]2026 Jun;183(11):2857-2873. PMID: 41693050 -
CNS Neurosci Ther
A decrease in NR2B expression mediated by DNA hypermethylation induces perioperative neurocognitive disorder in aged mice. [Abstract]2023 May;29(5):1229-1242. PMID: 36694341 -
Neurobiol Dis
2025 Oct 15:215:107090. PMID: 40930427 -
Neurochem Int
Astroglial adrenoreceptors modulate synaptic transmission and contextual fear memory formation in dentate gyrus. [Abstract]2021 Feb:143:104942. PMID: 33340594 -
Sci Rep
PSD-95 in the anterior cingulate cortex contributes to neuropathic pain by interdependent activation with NR2B. [Abstract]2022 Oct 12;12(1):17114. PMID: 36224339 -
Neuropharmacology
A hippocampus dependent neural circuit loop underlying the generation of auditory mismatch negativity. [Abstract]2022 Mar 15:206:108947. PMID: 35026286 -
Exp Brain Res
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults. [Abstract]2023 Dec;241(11-12):2735-2750. PMID: 37845379 -
Purity & Documentation
References
[1]. Löschmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp Neurol. 2004 May;187(1):86-93. [Content Brief]
[2]. Szczurowska E,et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. [Content Brief]
[3]. Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 25-6981 hydrochloride Related Classifications
HY-13993B Related Classifications
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