2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. iGluR
  5. iGluR Activator

iGluR Activator

iGluR Activators (13):

Cat. No. Product Name Effect Purity
  • HY-N2370
    24-Hydroxycholesterol
    		Activator ≥99.0%
    24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
  • HY-18699
    CIQ
    		Activator 99.48%
    CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.
  • HY-12509
    PEPA
    		Activator 99.87%
    PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
  • HY-12597
    Quisqualic acid
    		Activator ≥98.0%
    Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica.
  • HY-17555
    Meclofenoxate hydrochloride
    		Activator 98.80%
    Meclofenoxate hydrochloride is an ester synthesized from DMAE and pCPA, which has the activity of stimulating memory and improving cognition.
  • HY-115864
    Osavampator
    		Activator 99.89%
    Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders.
  • HY-17553
    Coluracetam
    		Activator 99.87%
    Coluracetam(MKC-231) is a new choline uptake enhancer.
  • HY-10934
    Mibampator
    		Activator 99.86%
    Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
  • HY-10935
    LY450108
    		Activator 99.51%
    LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research.
  • HY-103235
    NPEC-caged-(S)-AMPA
    		Activator
    NPEC- caged-(S)-AMPA, a caged neurotransmitter analog, is a NPEC photoprotecting group caged the (S)-AMPA (HY-100815A) to make caged ligands specific for glutamate receptor sub-types. NPEC- caged-(S)-AMPA selectively activates AMPA receptor.
  • HY-P3340
    Leptin (116-130)
    		Activator
    Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD).
  • HY-125931
    Unifiram
    		Activator 99.78%
    Unifiram (DM232) is acts as a potent cognition enhancer through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research.
  • HY-149975
    AMPA receptor modulator-4
    		Activator
    AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice.