Meclofenoxate hydrochloride
Based on 1 Customer Validation
Meclofenoxate (Centrophenoxine) hydrochloride is an ester synthesized from DMAE and pCPA, capable of crossing the blood-brain barrier, and can stimulate memory and enhance cognition.
For research use only. We do not sell to patients.
- Purity: 98.33%
- CAS No.: 3685-84-5
- Formula: C12H17Cl2NO3
- Molecular Weight:294.17
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Meclofenoxate Hydrochloride (10 µM, 24 hours) significantly protects mitochondrial function in primary neurons, restoring mitochondrial morphology, reversing Rotenone (HY-B1756)-induced mitochondrial damage, and regulating redox balance[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine primary neurons (Parkinson’s disease model induced by Rotenone (HY-B1756))
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Concentration:10 µM
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Incubation Time:24 h
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Result:Restored mitochondrial function-related genes (Ndufa12, Cox6b1, Atp5k, Src) and reversed ROT-induced synaptic dysfunction by regulating Chrna4, Syt11, and Cdh8.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rotenone (HY-B1756)-induced Parkinson’s disease model in C57B/L mice[3]
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Dosage:50 µg/g
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Administration:Intraperitoneal injection (i.p.), once daily for 4 weeks
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Result:Reduced anhedonia in the sucrose preference test, improved motor deficits in behavioral tests.
Chemical Information
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CAS No. 3685-84-5
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Appearance Solid
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Molecular Weight 294.17
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Formula C12H17Cl2NO3
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Color White to off-white
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SMILES
ClC1=CC=C(OCC(OCCN(C)C)=O)C=C1.Cl
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Synonyms
Centrophenoxine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 50 mg/mL (169.97 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 33.33 mg/mL (113.30 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (339.94 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24. [Content Brief]
[2]. Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.3994 mL | 16.9970 mL | 33.9939 mL | 84.9849 mL |
| 5 mM | 0.6799 mL | 3.3994 mL | 6.7988 mL | 16.9970 mL | |
| 10 mM | 0.3399 mL | 1.6997 mL | 3.3994 mL | 8.4985 mL | |
| 15 mM | 0.2266 mL | 1.1331 mL | 2.2663 mL | 5.6657 mL | |
| 20 mM | 0.1700 mL | 0.8498 mL | 1.6997 mL | 4.2492 mL | |
| 25 mM | 0.1360 mL | 0.6799 mL | 1.3598 mL | 3.3994 mL | |
| 30 mM | 0.1133 mL | 0.5666 mL | 1.1331 mL | 2.8328 mL | |
| 40 mM | 0.0850 mL | 0.4249 mL | 0.8498 mL | 2.1246 mL | |
| 50 mM | 0.0680 mL | 0.3399 mL | 0.6799 mL | 1.6997 mL | |
| 60 mM | 0.0567 mL | 0.2833 mL | 0.5666 mL | 1.4164 mL | |
| 80 mM | 0.0425 mL | 0.2125 mL | 0.4249 mL | 1.0623 mL | |
| 100 mM | 0.0340 mL | 0.1700 mL | 0.3399 mL | 0.8498 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Meclofenoxate hydrochloride Related Classifications
HY-17555 Related Classifications
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