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Simufilam hydrochloride (Synonyms: PTI-125 hydrochloride)

Cat. No.: HY-139142B
Handling Instructions

Simufilam (PTI-125) (hydrochloride) is a low toxicity, orally active filamin A (FLNA) activator. Simufilam (hydrochloride) preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam (hydrochloride) can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

Simufilam hydrochloride Chemical Structure

Simufilam hydrochloride Chemical Structure

CAS No. : 2480226-07-9

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Based on 1 publication(s) in Google Scholar

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Description

Simufilam (PTI-125) (hydrochloride) is a low toxicity, orally active filamin A (FLNA) activator. Simufilam (hydrochloride) preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam (hydrochloride) can be used for the research of Alzheimer's disease[1].

IC50 & Target

FLNA[1]

In Vitro

Simufilam (1 pM~1 nM) (hydrochloride) dose-dependently improves NMDA/glycine-induced Arc expression[1].
Simufilam (1 nM, 1 hour) (hydrochloride) largely restores filamin A to its native conformation and is effective in normalizing receptor activities in AD frontal cortices. Simufilam (hydrochloride) dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam (hydrochloride) reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Simufilam (P.o.; 2 months) (hydrochloride) restores FLNA to its native conformation. Simufilam (22 mg/kg; p.o.) (hydrochloride) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam (hydrochloride) significantly improves spatial memory. Simufilam (hydrochloride) significantly improves working memory[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

295.81

Formula

C₁₅H₂₂ClN₃O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Simufilam hydrochloride
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HY-139142B
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