2480226-07-9
Chemical Structure
Simufilam hydrochloride
Synonym(s): PTI-125 hydrochloride
- CAS No.: 2480226-07-9
- Formula:C15H22ClN3O
- Molecular Weight:295.81
IUPAC Name: 1-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one hydrochloride
InChIKey: PTJPWAGPMQSZSP-UHFFFAOYSA-N
SMILES: O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
Biological Activity: Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. Simufilam hydrochloride restores NMDAR signaling and Arc expression. Simufilam hydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride can be used for research of Alzheimer's disease[1][2][3].
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Simufilam hydrochloride | 99.85% | Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. Simufilam hydrochloride restores NMDAR signaling and Arc expression. Simufilam hydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam hydrochloride can be used for research of Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Wang HY, et al. Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes. Front Aging. 2023 Jun 29;4:1175601. [Content Brief]
- [2]. Wang HY, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012 Jul 18;32(29):9773-84. [Content Brief]
- [3]. Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017 Jul;55:99-114. [Content Brief]
Keywords
