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Simufilam dihydrochloride (Synonyms: PTI-125 dihydrochloride)

Cat. No.: HY-139142A
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Simufilam (PTI-125) dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam dihydrochloride can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

Simufilam dihydrochloride Chemical Structure

Simufilam dihydrochloride Chemical Structure

CAS No. : 2480226-06-8

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Description

Simufilam (PTI-125) dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam dihydrochloride can be used for the research of Alzheimer's disease[1].

IC50 & Target

FLNA[1]

In Vitro

Simufilam dihydrochloride (1 pM~1 nM) dose-dependently improves NMDA/glycine-induced Arc expression[1].
Simufilam dihydrochloride (1 nM, 1 hour) largely restores filamin A to its native conformation and is effective in normalizing receptor activities in AD frontal cortices. Simufilam dihydrochloride dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam dihydrochloride reduces Ab42's binding affinity for a7nAChR, thereby prevents Ab42's signaling and further accumulation on a7nAChRs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Simufilam dihydrochloride (P.o.; 2 months) restores FLNA to its native conformation. Simufilam dihydrochloride (22 mg/kg; p.o.) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam dihydrochloride significantly improves spatial memory. Simufilam significantly improves working memory[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

332.27

Formula

C₁₅H₂₃Cl₂N₃O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Simufilam dihydrochloride
Cat. No.:
HY-139142A
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