2480226-06-8
Chemical Structure
Simufilam dihydrochloride
Synonym(s): PTI-125 dihydrochloride
- CAS No.: 2480226-06-8
- Formula:C15H23Cl2N3O
- Molecular Weight:332.27
IUPAC Name: 1-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one dihydrochloride
InChIKey: IZIPGYSLPYPJDQ-UHFFFAOYSA-N
SMILES: O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl.[H]Cl
Biological Activity: Simufilam dihydrochloride (PTI-125 dihydrochloride) is an orally active FLNA modulator. Simufilam dihydrochloride restores NMDAR signaling and Arc expression. Simufilam dihydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam dihydrochloride can be used for research of Alzheimer's disease[1][2][3].
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Simufilam dihydrochloride | Simufilam dihydrochloride (PTI-125 dihydrochloride) is an orally active FLNA modulator. Simufilam dihydrochloride restores NMDAR signaling and Arc expression. Simufilam dihydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam dihydrochloride can be used for research of Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Wang HY, et al. Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes. Front Aging. 2023 Jun 29;4:1175601. [Content Brief]
- [2]. Wang HY, et al. Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012 Jul 18;32(29):9773-84. [Content Brief]
- [3]. Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017 Jul;55:99-114. [Content Brief]
Keywords
