Nebracetam hydrochloride (Synonyms: WEB 1881 FU hydrochloride)

Name: Nebracetam hydrochloride
Brand: MedChemExpress
SKU: HY-113970A
Rating: 4.5 (1 reviews)

Cat. No.: HY-113970A Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Nebracetam hydrochloride, a nootropic M₁-muscarinic agonist, induces a rise of intracellular Ca²⁺ concentration. Nebracetam hydrochloride exhibits an EC₅₀ of 1.59 mM for elevating [Ca²⁺]_i.

For research use only. We do not sell to patients.

Nebracetam hydrochloride Chemical Structure

CAS No. : 1177279-49-0

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 94	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 94	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

In Vivo

Nebracetam (10 mg/kg, p.o.) involves not only cholinergic mechanisms but also involves lymbic and hippocampal noradrenergic mechanisms^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 200-250 g^[2].
Dosage:	10, 20 mg/kg.
Administration:	P.O. (single dose).
Result:	Able to correct this scopolamine-induced disruption of spatial cognition.

Molecular Weight

240.73

Formula

C₁₂H₁₇ClN₂O

CAS No.

1177279-49-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC2=CC=CC=C2)CC(CN)C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (415.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1540 mL	20.7702 mL	41.5403 mL
5 mM	0.8308 mL	4.1540 mL	8.3081 mL
10 mM	0.4154 mL	2.0770 mL	4.1540 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) LCMS (120 KB)

Handling Instructions (2659 KB)

References

[1]. Kitamura Y, et al. Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. Jpn J Pharmacol. 1991 Jan;55(1):177-80. [Content Brief]

[2]. Iwasaki K, et al. Effect of nebracetam on the disruption of spatial cognition in rats. Jpn J Pharmacol. 1992 Feb;58(2):117-26. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1540 mL	20.7702 mL	41.5403 mL	103.8508 mL
	5 mM	0.8308 mL	4.1540 mL	8.3081 mL	20.7702 mL
	10 mM	0.4154 mL	2.0770 mL	4.1540 mL	10.3851 mL
	15 mM	0.2769 mL	1.3847 mL	2.7694 mL	6.9234 mL
	20 mM	0.2077 mL	1.0385 mL	2.0770 mL	5.1925 mL
	25 mM	0.1662 mL	0.8308 mL	1.6616 mL	4.1540 mL
	30 mM	0.1385 mL	0.6923 mL	1.3847 mL	3.4617 mL
	40 mM	0.1039 mL	0.5193 mL	1.0385 mL	2.5963 mL
	50 mM	0.0831 mL	0.4154 mL	0.8308 mL	2.0770 mL
	60 mM	0.0692 mL	0.3462 mL	0.6923 mL	1.7308 mL
	80 mM	0.0519 mL	0.2596 mL	0.5193 mL	1.2981 mL
	100 mM	0.0415 mL	0.2077 mL	0.4154 mL	1.0385 mL

Nebracetam hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nebracetam1177279-49-0WEB 1881 FUmAChRMuscarinic acetylcholine receptor2-deoxyglucose2-DGAlzheimer'sCa2+Inhibitorinhibitorinhibit

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Nebracetam hydrochloride (Synonyms: WEB 1881 FU hydrochloride)

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Nebracetam hydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

Nebracetam hydrochloride Related Classifications

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